コンテンツメニュー

Matsumoto Toshihiko

Affiliate Master Yamaguchi University

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山口医学 Volume 70 Issue 3 pp. 89 - 98
published_at 2021-09-01
We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.
Gastroenterology Volume 54 Issue 6 pp. 690 - 693
published_at 2012-06
Creators : 寺井 崇二 Oono Takashi 在津 潤一 大石 俊之 桑代 紳哉 松本 俊彦 橋本 真一 岡本 健志 戒能 聖治 内田 耕一 坂井田 功 Publishers : 科学評論社
Journal of gastroenterology
published_at 2012-04-05
Creators : Terai Shuji Tanimoto Haruko Maeda Masaki Zaitsu Junichi Hisanaga Takuro Iwamoto Takuya Fujisawa Koichi Mizunaga Yuko Matsumoto Toshihiko Urata Yohei Marumoto Yoshio Hidaka Isao Ishikawa Tsuyoshi Yokoyama Yuichiro Aoyama Koji Tsuchiya Masako Takami Taro Omori Kaoru Yamamoto Naoki Segawa Makoto Uchida Koichi Yamasaki Takahiro Okita Kiwamu Sakaida Isao Publishers : Springer international | Springer-Verlag
Cell and tissue research Volume 344 Issue 1 pp. 125 - 134
published_at 2011-04
Creators : Kuwashiro Shinya Terai Shuji Oishi Toshiyuki Fujisawa Koichi Matsumoto Toshihiko Nishina Hiroshi Sakaida Isao Publishers : Springer