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Hobara Tatsuya

Affiliate Master Yamaguchi University

Effects of 1, 1, 1-Trichloroethance Inhalation on Respiration and Blood Gas Tension

山口医学 Volume 33 Issue 5 Page 387-392
published_at 1984-10
Title
1,1,1-Trichloroethane 吸入暴露による呼吸と血液ガス分圧の変化
Effects of 1, 1, 1-Trichloroethance Inhalation on Respiration and Blood Gas Tension
Creators Kobayashi Haruo
Creators Hobara Tatsuya
Creators Kawamoto Toshihiro
Creators Higashihara Eiji
Creators Sato Toshinobu
Creators Tanaka Haruko
Creators Iwamoto Susumu
Creators Sakai Tsunemi
Source Identifiers
Changes in respiration and arterial blood gas tension following 1, 1, 1 -trichloroethane (1, 1, 1 -TCE) inhalation were investigated in anesthetized dogs. In acute in halation experiments, both increase in respiratory rate and a decrease in amplitude of respiration were observed following inhalation of higher 1, 1, 1 -TCE concentrations. The threshold concentration of 1, 1, 1 -TCE required to produce a increase in respiratory rate was approximately 0.7 to 0.9% in inspired air, and dose response relationship between the increase in respiratory rate and 1, 1, 1 -TCE concentrations which exceeded the threshold level was observed. Moreover, a trancient increase in arterial oxygen tension, a decrease in carbon dioxide tension and an increase in pH were observed following inhalation of higher 1, 1, 1 -TCE concentrations in spontaneous breathing. However, oxygen tension, carbon dioxide tension and pH remained unchanged following inhalation in artificial breathing. It is suggested that alterations of blood gas tension and pH may be based on mainly the increase in respiratory rate resulting from 1, 1, 1 -TCE inhalation in anesthetized dogs.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1984-10
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部