Futher Examples of Hemoglobin Hirose ： Study of Molecular Stability

Creators Ohba Yuzo

Creators Hattori Yukio

Creators Takeda Isamu

Creators Fuyuno Kikuo

Creators Matsuoka Miyoko

Creators Yoshinaka Hiroshi

Creators Satoh Tomoki

Creators Miyaji Takaoki

Two new cases of Hb Hirose,β37 (CⅢ) Trp→Ser, are reported. Hemoglobin Hirose exhibits propreties, a high oxygen affinity and slightly increased rates of autooxidation, heat denaturation and precipitation on mechanical shaking. These unique properties of Hb Hirose seem to depend on the abnormal manner of association of the aberrant β subunit with the α submit and on the enhanced tendency to dissociate intosubunits. In spite of the abnormal functional properties and the molecular instability of the hemoglobin, none of the carries of Hb Hirose reported so far (only four unrelated Japanese in the world) manifested erythrocytosis or a hemolytic disorder, presumably because the dissociation into subnit is prevent in vivo by the very high hemogrobin concentration in the red blood cell.

[ISSN]0513-1812

[NCID]AA00594272