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Matsuzaki Masanori

Affiliate Master Yamaguchi University

Creators : Sugihara Nobuyuki Kumada Toshiaki Ozaki Masaharu Okayama Akira Matsuzaki Masanori Matsuda Yasuo Kusukawa Reizo Publishers : Yamaguchi University Graduate School of Medicine
Creators : Itagaki Tatsunori Ishizaki Hirohumi Matsuo Kiyohiro Uchino Fumiya Uchiyama Kazutoshi Yonezawa Fumio Hatao Masako Yamamoto Norio Hayashida Shigeaki Matsuzaki Masunori Publishers : Yamaguchi University Graduate School of Medicine
Creators : Iwami Takahiro Matsutani Akira Umemoto Seiji Yamada Hiroatsu Matsuzaki Masunori Publishers : Yamaguchi University Graduate School of Medicine
山口医学 Volume 24 Issue 3 pp. 195 - 202
published_at 1975-09
Creators : Yamamoto Toru Fujita Takaki Sadakane Akito Fukuda Shinji Ozaki Masaharu Iwamoto Setuko Matuzaki Masunori Publishers : 山口大学医学会
Creators : Sugihara Nobuyuki Matsuzaki Masunori Furutani Kaneto Kato Yukiko Miyawaki Muneo Publishers : Yamaguchi University Graduate School of Medicine
Creators : Mitani Reo Haraguchi Masahiko Harada Nozomu Takata Satoko Dairaku Yuka Kimura Masahiro Matsuzaki Masunori Publishers : Yamaguchi University Graduate School of Medicine
Proceedings of the International Conference on Control, Automation and Systems pp. 875 - 878
published_at 2001
Creators : Jiang Zhongwei Yamada Kazuhiro Fujii Takashi Matsuzaki Masunori
Journal of atherosclerosis and thrombosis Volume 17 Issue 8 pp. 785 - 795
published_at 2010-08
Creators : Hashimoto Ryo Umemoto Seiji Guo Fengling Umeji Kyoko Itoh Shinichi Kishi Hiroko Kobayashi Sei Matsuzaki Masunori Publishers : 日本動脈硬化学会
Atherosclerosis Volume 219 Issue 2 pp. 743 - 749
published_at 2011-12
Creators : Hibi Kiyoshi Kimura Takeshi Kimura Kazuo Morimoto Takeshi Hiro Takafumi Miyauchi Katsumi Nakagawa Yoshihisa Yamagishi Masakazu Ozaki Yukio Saito Satoshi Yamaguchi Tetsu Daida Hiroyuki Matsuzaki Masunori Publishers : Elsevier | Elsevier Science Ireland
Cardiovascular drugs and therapy Volume 25 Issue Supplement 1 pp. 19 - 31
published_at 2011-12
Creators : Matsuzaki Masanori Hori Masatsugu Izumi Tohru Asanoi Hidetsugu Tsutamoto Takayoshi Publishers : Nijhoff
Cardiovascular drugs and therapy Volume 25 Issue Supplement 1 pp. 47 - 56
published_at 2011-12
Creators : Fukunami Masatake Matsuzaki Masunori Hori Masatsugu Izumi Tohru Publishers : Nijhoff
Cardiovascular drugs and therapy Volume 25 Issue Supplement 1 pp. 57 - 65
published_at 2011-12
Creators : Inomata Takayuki Izumi Tohru Matsuzaki Masunori Hori Masatsugu Hirayama Atsushi Publishers : Nijhoff
Cardiovascular research Volume 89 Issue 1 pp. 79 - 88
published_at 2011-01-01
Creators : Aoyama Hidekazu Ikeda Yasuhiro Miyazaki Yosuke Yoshimura Koichi Nishino Shizuka Yamamoto Takeshi Yano Masafumi Inui Makoto Aoki Hiroki Matsuzaki Masunori Publishers : British Medical Association | Elsevier Science
Cardiovascular ultrasound Volume 9 pp. 30 -
published_at 2011-11
Creators : Murata Kazuya Ueyama Takeshi Tanaka Takeo Nose Yoshio Wada Yasuaki Matsuzaki Masunori Publishers : BioMed Central
Cardiovascular drugs and therapy Volume 25 Issue Supplement 1 pp. 33 - 46
published_at 2011-12
Creators : Matsuzaki Masanori Hori Masatsugu Izumi Tohru Fukunami Masatake Publishers : Nijhoff
Circulation journal : official journal of the Japanese Circulation Society Volume 75 Issue 12 pp. 2840 - 2846
published_at 2011
Creators : Daimon Masao Watanabe Hiroyuki Abe Yukio Hirata Kumiko Hozumi Takeshi Ishii Katsuhisa Ito Hiroshi Iwakura Katsuomi Izumi Chisato Matsuzaki Masunori Minagoe Shinichi Abe Haruhiko Murata Kazuya Nakatani Satoshi Negishi Kazuaki Yoshida Ken Tanabe Kazuaki Tanaka Nobuhiro Tokai Kotaro Yoshikawa Junichi Publishers : Japanese Circulation Society
Circulation journal : official journal of the Japanese Circulation Society Volume 76 Issue 2 pp. 453 - 461
published_at 2012
Creators : Otsuka Haruna Arimura Takuro Abe Tadaaki Kawai Hiroya Aizawa Yoshiyasu Kubo Toru Kitaoka Hiroaki Nakamura Hiroshi Nakamura Kazufumi Okamoto Hiroshi Ichida Fukiko Ayusawa Mamoru Nunoda Shinichi Isobe Mitsuaki Matsuzaki Masunori L. Doi Yoshinori Fukuda Keiichi Sasaoka Taishi Izumi Toru Ashizawa Naoto Kimura Akinori Publishers : Japanese Circulation Society
Progress in medicine Volume 32 Issue Suppl pp. 510 - 513
published_at 2012-03-07
Creators : 加藤 孝佳 上山 剛 土居 正浩 吉田 雅昭 平塚 淳史 福田 昌和 文本 朋子 Matsuzaki Masanori 清水 昭彦 Publishers : ライフ・サイエンス
Creators : Sugihara Nobuyuki Matsuzaki Masunori Furutani Kaneto Kato Yukio Miyawaki Muneo Publishers : Yamaguchi University Graduate School of Medicine
Creators : Oda Tetsuro Yano Masafumi Matsuzaki Masunori Publishers : Yamaguchi University School of Medicine
山口医学 Volume 40 Issue 5 pp. 517 - 523
published_at 1991-10
Creators : Haraguchi Masahiko Yamagishi Takashi Saiki Atsushi Seto Fumio Furutani Yuji Matsuda Masako Ozaki Masaharu Matsuzaki Masunori Kusukawa Reizo Publishers : 山口大学医学会
山口医学 Volume 28 Issue 3-4 pp. 343 - 352
published_at 1979-12
Creators : Fuji Yasuhiro Tomosawa Naofumi Furukawa Shoichi Oda Tatsurou Yamaki Rikio 松﨑 益徳 萬 忠雄 深川 和英 Publishers : 山口大学医学会
Electrocardiology Volume 32 Issue Supplement 3 pp. 53 - 60
published_at 2012-05-18
Creators : Fumimoto Tomoko Shimizu Akihiko Ueyama Takeshi Doi Masahiro Hiratsuka Atsushi Yoshida Masaaki Fukuda Masakazu Katoh Takayoshi Kimura Masayasu Takita Satoru Itagaki Kazuo Matsuzaki Masunori Publishers : 日本心電学会
Circulation journal : official journal of the Japanese Circulation Society Volume 76 Issue 2 pp. 489 - 507
published_at 2012-01-25
Creators : Aizawa Yoshifusa Horie Minoru Inoue Hiroshi Kamakura Shiro Katoh Takao Matsuzaki Masunori Misaki Takuro Mitamura Hideo Murakawa Yuji Nitta Takashi Ogawa Satoshi Okumura Ken Sumitomo Naokata Yoshinaga Masao Chinushi Masaomi Fujiki Akira Furushima Hiroshi Ikeda Takanori Ito Makoto Kuga Keisuke Kusano Kengo Niwano Shinichi Nohara Ryuji Sasaki Shingo Shimizu Akihiko Shimizu Wataru Shoda Morio Hori Masatsugu Nakazawa Makoto Sugimoto Tsuneaki Yamaguchi Tetsu Publishers : Japanese Circulation Society
Journal of atherosclerosis and thrombosis Volume 19 Issue 2 pp. 194 - 204
published_at 2012-02-25
Creators : Sasaki Jun Yokoyama Mitsuhiro Matsuzaki Masunori Saito Yasushi Origasa Hideki Ishikawa Yuichi Oikawa Shinichi Itakura Hiroshige Hishida Hitoshi Kita Toru Kitabatake Akira Nakaya Noriaki Sakata Toshiie Shimada Kazuyuki Shirato Kunio Matsuzawa Yuji Publishers : Japan Atherosclerosis Society
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by stress- or exercise- induced ventricular tachycardia, frequently leading to sudden cardiac death. A considerable body of evidence accumulated over recent years suggests that mutation-linked cardiac ryanodine receptor (RyR2) defects cause Ca^2+ leak from sarcoplasmic reticulum, which triggers delayed afterdepolarization and leads to CPVT. However, the underlying mechanism, by which a single mutation in such a large molecule causes drastic effects on the channel function, remains elusive. Here we report that introduction of a human CPVT mutation S2246L into the mouse RyR2 induces aberrant activation of channel gating by forming abnormally tight domain-domain interaction between the S2246L mutable domain and the K201-binding domain. This produces more global conformational change in the RyR2: namely, an aberrant domain unzipping between the N-terminal (a.a. 1–600) domain and the central (a.a. 2000–2500) domain owing to the allosteric conformational coupling mechanism. Pharmacological correction of the defective inter-domain interactions can stop the aberrant Ca^2+ release and lethal arrhythmia. These results provide a new pathogenic mechanism of CPVT and a novel therapeutic strategy against CPVT
Creators : Suetomi Takeshi Yano Masafumi Matsuzaki Masanori Publishers : Yamaguchi University School of Medicine
Background: Angiotensin II (AngII) increases reactive oxygen species (ROS) and induces glomerular sclerosis. Toll-like receptor 4 (TLR4)-mediated inflammation enhances the renal impairment in renal inflammatory diseases. The relationship between TLR4 and AngII-induced glomerular sclerosis is unknown.Methods: Mice lacking TLR4 function (Tlr4^{lps-d}) and wild-type (WT) mice were randomized into groups treated with AngII, norepinephrine (NE) or a sub-depressor dose of the AngII receptor blocker irbesartan along with AngII for 2 weeks. We then assessed the expressions of NADPH oxidase and monocyte chemoattractant protein-1 (MCP-1) and the inflammatory cell recruitment in the glomeruli. We also evaluated the mesangial matrix proliferation and ROS.Results: AngII and NE equally increased the systolic blood pressure compared to the control mice (p<0.05). In the WT mice treated with AngII, we observed glomerular sclerosis, an increase in NADPH oxidase, MCP-1 and the infiltration of macrophages as well as ROS content in the glomeruli compared to the control mice (p<0.05), whereas the Tlr4^{lps-d} mice showed little effects of AngII on these indices. In addition, the sub-depressor-dose irbesartan treatment reversed these changes. NE had little effects on these indices. Conclusions: TLR4 plays an important role in AngII-induced oxidative stress, inflammation and glomerular sclerosis through the AT1 receptor.
Creators : Okamoto Tadashi Umemoto Seiji Yoshimura Koichi Sakumura Toshihiro Murata Tomoaki Fukai Tohru Yano Masafumi Matsuzaki Masanori Publishers : Yamaguchi University School of Medicine
We investigated the relationship between myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy (TC) compared with acute anteroseptal myocardial infarction (AMI). Methods: In 10 TC patients and 10 AMI patients, electrocardiogram, echocardiography, cardiac catheterization were conducted, and plasma catecholamines and urinary (U) 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage were taken for one week from onset. Results: On admission, the coronary sinus (CS) had significantly higher norepinephrine (NE) and 8-OHdG levels than the aortic root (Ao) and peripheral blood vessels. Circulating catecholamines in TC patients tended to be higher than those in AMI patients
Aberrant increases in protein phosphatase 1(PP1) activity have been shown to be associated with inefficient sarcoplasmic reticulum Ca^{2+} cycling, leading to cardiac dysfunction in the failing heart. In the present study, we investigated whether BNP promoter-inducible suppression of PP1β would ameliorate progression of pressure overload-induced heart failure in mice, a clinically relevant animal model. An Adeno-associated virus 9 (AAV9) vector encoding PP1βshRNA and a negative control (NC) shRNA driven by a brain natriuretic peptide (BNP) promoter with an emerald green fluorescent protein expression (EmGFP) cassette were used to test the hypothesis. AAV9 vectors (AAV9-BNP-EmGFP-PP1βshRNA and AAV9-BNP-EmGFP-NCshRNA) were introduced into the in vivo heart via the tail vein injection (4x10^{11} GC/mice) in 8-week-old C57BL6J mice, followed by transverse aortic constriction (TAC) 2 weeks after the AAV9 vector injection. Post TAC cardiac function was sequentially assessed every 2 week by echocardiography, followed by hemodynamic assessment at 1 month. AAV9-BNP-EmGFP-PP1βshRNA treatment suppressed myocardial PP1β expression by 15% compared with the NCshRNA group (p<0.001). The fractional shortening (%FS) of the left ventricle in the PP1βshRNA-treated group was significantly larger than the NCshRNA-treated group (21%±1.0% vs. 15%±0.01, p<0.01). The ratios of heart weight (HW) / body weight (BW) and lung weight (LW) / BW in the PP1βshRNA group were significantly smaller than those of the NCshRNA group (HW/BW: 9.20±0.49 vs. 10.6±0.45 mg/g
Creators : Shiraishi Kozo Ikeda Yasuhiro Miyazaki Yosuke Fujimoto Shizuka N. Yoshimura Koichi Miura Toshiro Matsuzaki Masanori Yano Masafumi Publishers : Yamaguchi University School of Medicine
山口医学 Volume 25 Issue 2 pp. 77 - 88
published_at 1976-06
Creators : Nomoto Kunihiro Shiiki Toshihiko Tanioka Takeshi Ikee Yoshinobu Maeda Setsuya Matsuzaki Masunori Okabe Mitsuhisa Wada Kazunari Mise Junichi Publishers : 山口大学医学会
山口医学 Volume 29 Issue 1 pp. 41 - 52
published_at 1980-03
Creators : Moriyama Katsutoshi Matsuzaki Masunori Yorozu Tadao Isida Ken Kusuyama Reizo Mise Junichi Maeda Junya Sasada Takayoshi Komoda Makoto Anno Yoshito Publishers : 山口大学医学会
山口医学 Volume 39 Issue 1 pp. 121 - 125
published_at 1990-02
Creators : Fujino Hisako Tada Toshihiko Fujii Zenzoh Sawachika Takashi Matsuzaki Masunori Kusukawa Reizoh Publishers : 山口大学医学会
Proceedings of the International Conference on Mechatronics and Information Technology Volume 75BM pp. 181 - 184
published_at 2001
Creators : Jiang Zhongwei Yamada Kazuhiro Kim Il Hwan Fujii Takashi Shimizu Seiji Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society Volume 75 Issue 8 pp. 1825 - 1826
published_at 2011
Creators : Murata Kazuya Matsuzaki Masunori Publishers : Japanese Circulation Society
Circulation journal : official journal of the Japanese Circulation Society Volume 76 Issue 4 pp. 825 - 832
published_at 2012
Creators : Miyauchi Katsumi Daida Hiroyuki Morimoto Takeshi Hiro Takafumi Kimura Takeshi Nakagawa Yoshihisa Yamagishi Masakazu Ozaki Yukio Kadota Kazushige Kimura Kazuo Hirayama Atsushi Kimura Kazumi Hasegawa Yasuhiro Uchiyama Shinichiro Matsuzaki Masunori Publishers : Japanese Circulation Society
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology Volume 13 Issue 1 pp. 29 - 36
published_at 2011-01
Creators : Kobayashi Shigeki Susa Takehisa Tanaka Takeo Wada Yasuaki Okuda Shinichi Doi Masahiro Nao Tomoko Yoshiga Yasuhiro Yamada Jutaro Okamura Takayuki Ueyama Takeshi Kawamura Syuji Yano Masafumi Matsuzaki Masunori Publishers : Elsevier | European Society of Cardiology
心臓 Volume 43 Issue Suppl.2 pp. 52 - 57
published_at 2011
Creators : Katoh Takayoshi Shimizu Akihiko Ueyama Takeshi Doi Masahiro Ohmiya Toshihide Yoshida Masakazu Hiratsuka Atsushi Fukuda Masakazu Matsuzaki Masanori Publishers : 医事通信社
Therapeutic research Volume 33 Issue 9 pp. 1348 - 1349
published_at 2012-09-20
Creators : 板垣  和夫 瀧田 覚 関 耕三郎 佐々木 徹 清水 昭彦 Matsuzaki Masanori Publishers : Life Science Publishing