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Shinoda Koh

Affiliate Master Yamaguchi University

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Creators : Rahman Md. Shamsur Yanai Kazutoshi Kawata Keisuke Okumura Tadashi Shinoda Koh Publishers : Yamaguchi University Graduate School of Medicine
Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators : Okita Kiwamu Sakaida Isao Terai Shuji Yamamoto Naoki Omori Kaoru Ishikawa Tsuyoshi Aoyama Kouji Shinoda Koh Hamamoto Yoshihiko Publishers : Yamaguchi University School of Medicine
Experimental cell research Volume 317 Issue 12 pp. 1689 - 1700
published_at 2011-07-15
Creators : Fujinaga Ryutaro Takeshita Yukio Yoshioka Kazuhiro Nakamura Hiroyuki Shinoda Shuhei Islam Md. Nabiul Jahan Mir Rubayet Yanai Akie Kokubu Keiji Shinoda Koh Publishers : Academic Press
Pakistan veterinary journal Volume 32 Issue 2 pp. 175 - 178
published_at 2012
Creators : Islam M.N. Khan M.Z.I. Jahan M.R. Fujinaga R. Yanai A. Kokubu K. Shinoda K. Publishers : Faculty of Veterinary Science, University of Agriculture
山口医学 Volume 48 Issue 4 pp. 143 - 147
published_at 1999-08
Creators : Shinoda Akira Publishers : 山口大学医学会