コンテンツメニュー

Abe Noritaka

Affiliate Master Yamaguchi University

Reductive cyclization of 8-(2-nitrophenyl)-1-azaazulene derivatives; formation of 6a,7-diazanaphth[3,2,1-cd]azulene and 7H-1,7-diazaindeno[1,2-e]azulene systems, a new DNA intercalater

Heterocycles Volume 54 Issue 1 Page 329-339
published_at 2001
2007020162.pdf
[fulltext] 3.2 MB
Title
Reductive cyclization of 8-(2-nitrophenyl)-1-azaazulene derivatives; formation of 6a,7-diazanaphth[3,2,1-cd]azulene and 7H-1,7-diazaindeno[1,2-e]azulene systems, a new DNA intercalater
Creators Abe Noritaka
Creators Nabeshima Maki
Creators Fujii Hiroyuki
Creators Kakehi Akikazu
Creators Kageura Yuichi
Creators Konakahara Takeo
Reaction of ethyl 2-dimethylamino-8-(2-nitrophenyl)-1-azaazulene-3-carboxylate with hexamethylphosphorous triamide gave ethyl 6-dimethylamino-6a,7-diazanaphth[3,2,1-cd]azulene-5-carboxylate (7b) and ethyl 2-dimethylamino-7H-1,7-diazaindeno[1,2-e]azulene-3-carboxylate (8b). The structures of 7b and 8b were determined by X-Ray structure analyses. Compound (8b) was intercalated to Calf-Thymus DNA and a 12-mer DNA with binding constants K_D=1.55×10^6 and 1.75×10^6 M^<-1>, respectively.
Languages eng
Resource Type journal article
Publishers 日本複素環化学研究所
Date Issued 2001
File Version Version of Record
Access Rights open access
Relations
[ISSN]0385-5414
[NCID]AA00663739
Schools 大学院医学系研究科(理学) 総合科学実験センター