Japanese | English

トップページへ戻る

詳細

   
フルテキストURLA050067000302.pdf ( 444.1KB ) 公開日 2020-11-11
タイトルAn invited review following the Soujinkai Young Investigator Award : calreticulin is highly expressed in pancreatic cancer stem-like cells
作成者Matsukuma, Satoshi
Yoshimura, Kiyoshi
Tsunedomi, Ryouichi
Hazama, Shoichi
Nagano, Hiroaki
作成者ヨミマツクマ, サトシ
ヨシムラ, キヨシ
ツネドミ, リョウイチ
ハザマ, ショウイチ
ナガノ, ヒロアキ
作成者別表記松隈, 聰
吉村, 清
恒富, 亮一
硲, 彰一
永野, 浩昭
作成者所属山口大学大学院医学系研究科(医学)
山口大学医学部
内容記述(抄録等)Pancreatic cancer is an intractable disease with a poor prognosis. Recent research has demonstrated that the resistance of these cancers to conventional treatment, the high rate of local recurrence and distant metastasis may be attributed to a small subset of cells in cancer tissues known as cancer stem-like cells. It is critically important to elucidate the biological properties of cancer stem-like cells and develop strategies targeting these cells to overcome pancreatic cancers. We established a pancreatic cancer stem-like cell induction method from a cancer cell line and identified calreticulin as a highly expressed protein on the surface of these cells using proteomics and flow cytometry. Notably, we demonstrated that calreticulin was expressed on cells with high ATP-binding cassette transporter activity known to mediate drug efflux and related to poor outcomes in pancreatic cancer patients who underwent curative resection. Calreticulin exposure in cancer stem-like cells could be regulated by oxidative stress via hypoxia-inducible factors which induce the expression of CD47 and PD-L1 to evade the immune-surveillance of these cells. Further investigations on calreticulin expression in pancreatic cancer stem-like cells could elucidate the pathophysiology of these cells, leading to the development of novel therapy.
本文言語eng
著者キーワードpancreatic cancer
cancer stem-like cells
calreticulin
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
67
3-4
開始ページ19
終了ページ23
発行日2020
著者版/出版社版出版社版
リポジトリIDA050067000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050067000302