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フルテキストURLA050067000301.pdf ( 1.1MB ) 公開日 2020-11-11
タイトルAn invited review following the Soujinkai Award : development of novel chimeric antigen receptor-expressing t cells promoting immune cell infiltration and survival in the tumor tissue
作成者Adachi, Keishi
Tamada, Koji
作成者ヨミアダチ, ケイシ
タマダ, コウジ
作成者別表記安達, 圭志
玉田, 耕治
作成者所属山口大学大学院医学系研究科(医学)
内容記述(抄録等)Chimeric Antigen Receptor (CAR) -T cell therapy is attracting the attention for its remarkable therapeutic efficacy on hematological malignancies. Meanwhile, some serious issues currently remain in CAR-T cell therapy, one of which is the ineffectiveness against solid tumors. In order to overcome the issue, we developed the next generation CAR-T cell which simultaneously produce IL-7 and CCL19 (7×19 CAR-T cell). In several solid tumor mouse models, administration of 7 × 19 CAR-T cells induced conspicuous infiltrations of T cells and dendritic cells (DCs) inside the tumor tissues, and exert potent antitumor efficacies in cooperation with the recipient T cells. In addition, a long-term immunological memory against the tumor was formed after the treatment, suggesting that the treatment with 7×19 CAR-T cells enabled the prevention of cancer recurrence. In conclusion, our study concerning the next-generation CAR-T cell is expected to lead an innovative therapy against solid tumors.
本文言語eng
著者キーワードsolid tumor
T cell 
CAR-T cell
IL-17
CCL19
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
67
3-4
開始ページ11
終了ページ17
発行日2020
著者版/出版社版出版社版
リポジトリIDA050067000301
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050067000301