フルテキストURL | A050066000101.pdf ( 1.1MB ) 公開日 2019-09-20
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タイトル | An invited review following the Soujinkai Young Investigator Award : ryanodine receptor bound calmodulin as a novel therapeutic target of arrhythmias and heart failure |
作成者 | Kato, Takayoshi
Yamamoto, Takeshi
Kobayashi, Shigeki
Yano, Masafumi
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作成者ヨミ | カトウ, タカヨシ
ヤマモト, タケシ
コバヤシ, シゲキ
ヤノ, マサフミ
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作成者別表記 | 加藤, 孝佳
山本, 健
小林, 茂樹
矢野, 雅文
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作成者所属 | 山口大学大学院医学系研究科(医学)
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内容記述(抄録等) | Life-threatening situations that can arise in patients with heart failure are widely recognized in clinical cardiology. This occasionally results from ventricular arrhythmias and hence the management of lethal arrhythmias is now one of the most important issues in the treatment of heart failure. In the failing cardiomyocytes, an abnormal regulation of intracellular calcium (Ca^{2+}) handling by a Ca^{2+} release channel of the sarcoplasmic reticulum (SR), so-called ryanodine receptor (RyR2), is known to play an important role in the mechanism underlying cardiac arrhythmias. On the other hand, in catecholaminergic polymorphic ventricular tachycardia (CPVT), mutation- linked defective channel gating of the RyR2 is also known as a major pathogenic mechanism underlying fatal arrhythmias. The knowledge gained from these studies upon the RyR2 and its modulatory proteins, such as calmodulin (CaM), may lead to the development of a new pharmacological or genetic strategy for the treatment of heart failure and cardiac arrhythmias. In this review, we focused on the role of CaM on the regulation of the channel gating of the RyR2 in the pathogenesis of heart failure and fatal arrhythmias, and discuss the possibility of developing a novel therapeutic strategy targeting the RyR2.
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本文言語 | eng
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著者キーワード | heart failure
lethal arrhythmia
cardiac ryanodine receptor
calmodulin
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資料タイプ | text |
ファイル形式 | application/pdf |
出版者 | Yamaguchi University School of Medicine
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NII資料タイプ | 紀要論文 |
ISSN | 0513-1812
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NCID | AA00594272
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学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
掲載誌名 | The bulletin of the Yamaguchi Medical School |
巻 | 66 |
号 | 1-2 |
開始ページ | 1 |
終了ページ | 6 |
発行日 | 2019 |
著者版/出版社版 | 出版社版 |
リポジトリID | A050066000101 |
地域区分 | 山口大学
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URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050066000101 |