| フルテキストURL | A050063000102.pdf ( 661.2KB ) 公開日 2016-09-23
|
|---|
| タイトル | Relationship between the myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy |
|---|
| 作成者 | Oda, Seiko
Kobayashi, Shigeki
Nanno, Takuma
Ishiguchi, Hironori
Myoren, Takeki
Murakami, Wakako
Mochizuki, Mamoru
Oda, Tetsuro
Okuda, Shinichi
Yamada, Jutaro
Okamura, Takayuki
Matsuzaki, Masunori
Yano, Masafumi
|
|---|
| 作成者ヨミ | オダ, セイコ
コバヤシ, シゲキ
ナンノ, タクマ
イシグチ, ヒロノリ
ミョウレン, タケキ
ムラカミ, ワカコ
モチヅキ, マモル
オダ, テツロウ
オクダ, シンイチ
ヤマダ, ジュタロウ
オカムラ, タカユキ
マツザキ, マスノリ
ヤノ, マサフミ
|
|---|
| 作成者別表記 | 小田, 聖子
小林, 茂樹
南野, 巧真
石口, 博智
明連, 武樹
村上, 和華子
望月, 守
小田, 哲郎
奥田, 真一
山田, 寿太郎
岡村, 誉之
松﨑, 益徳
矢野, 雅文
|
|---|
| 作成者所属 | 山口大学医学部附属病院
山口大学大学院医学系研究科（医学）
|
|---|
| 内容記述（抄録等） | We investigated the relationship between myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy (TC) compared with acute anteroseptal myocardial infarction (AMI). Methods: In 10 TC patients and 10 AMI patients, electrocardiogram, echocardiography, cardiac catheterization were conducted, and plasma catecholamines and urinary (U) 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage were taken for one week from onset. Results: On admission, the coronary sinus (CS) had significantly higher norepinephrine (NE) and 8-OHdG levels than the aortic root (Ao) and peripheral blood vessels. Circulating catecholamines in TC patients tended to be higher than those in AMI patients; especially, peripheral plasma NE levels (day 1) in patients with TC were significantly higher than those in patients with AMI. TC patients had elevated U-8-OHdG in parallel with elevated NE, whereas, AMI patients had U-8-OHdG level that decreased to almost normal range within one week. On day 1, in patients with TC, serum 8-OHdG differences (CS vs Ao) and U-8-OHdG increased proportionally with the wall-motion score as an index of LV dysfunction, whereas serum NE (CS vs Ao) did not. Conclusion: Myocardial oxidative stress induced by cardiac sympathetic hyperactivity may play a critical role in transient LV dysfunction in TC.
|
|---|
| 本文言語 | eng
|
|---|
| 著者キーワード | takotsubo cardiomyopathy
oxidative stress
catecholamine
|
|---|
| 資料タイプ | text |
|---|
| ファイル形式 | application/pdf |
|---|
| 出版者 | Yamaguchi University School of Medicine
|
|---|
| NII資料タイプ | 紀要論文 |
|---|
| ISSN | 0513-1812
|
|---|
| NCID | AA00594272
|
|---|
| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
|---|
| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
|---|
| 巻 | 63 |
|---|
| 号 | 1-2 |
|---|
| 開始ページ | 5 |
|---|
| 終了ページ | 16 |
|---|
| 発行日 | 2016 |
|---|
| 著者版/出版社版 | 出版社版 |
|---|
| リポジトリID | A050063000102 |
|---|
| 地域区分 | 山口大学
|
|---|
| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050063000102 |
|---|