| フルテキストURL | A050057000303.pdf ( 871.0KB ) 公開日 2011-03-29
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| タイトル | Analysis of single nucleotide polymorphisms of methylenetetrahydrofolate reductase in Japanese psoriasis patients |
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| 作成者 | Deguchi, Hirotaka
Tanaka, Akemi
Muto, Masahiko
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| 作成者ヨミ | デグチ, ヒロタカ
タナカ, アケミ
ムトウ, マサヒコ
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| 作成者別表記 | 出口, 弘隆
田中, 朱美
武藤, 正彦
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| 作成者所属 | 山口大学大学院医学系研究科（医学）
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| 内容記述（抄録等） | Methotrexate (MTX) is an effective drug for the treatment of psoriasis as well as rheumatoid arthritis. We investigated the correlation between single nucleotide polymorphisms (SNP) in methylenetetrahydrofolate reductase (MTHFR) and susceptibility to psoriasis in 175 psoriasis patients and 150 healthy controls and between MTHFR SNP and responsiveness to psoriasis treatment in 7 psoriasis patients. The frequencies of the 677C allele in the patient and healthy control groups were 0.61 and 0.57, respectively, while those of the 677T allele were 0.39 and 0.43, respectively. Both allele frequencies in both groups were not significantly different. Moreover, both groups showed the same frequency of 1298A allele (0.83 vs. 0.83) and 1298C allele (0.17 vs. 0.17). The frequency of MTHFR SNP and susceptibility to psoriasis were not correlated. Additionally, MTHFR SNP frequency and the psoriasis lesion were not correlated. Investigation of the MTX treatment efficacy in 7 patients revealed that the drug was effective in psoriasis patients with positive presumed 677C–1298A SNP haplotypes (N = 3), and they developed no side effects. Although MTHFR SNP involved in folate metabolism is not related to susceptibility to psoriasis and its severity, SNP could become a predictive index to use MTX safely and effectively in psoriasis treatment.
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| 本文言語 | eng
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| 著者キーワード | folic acid
methotrexate
methylenetetrahydrofolate reductase
polymorphism
disease susceptibility to psoriasis
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University School of Medicine
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| NII資料タイプ | 紀要論文 |
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 巻 | 57 |
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| 号 | 3-4 |
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| 開始ページ | 41 |
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| 終了ページ | 48 |
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| 発行日 | 2010 |
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| 関連情報URL(IsPartOf) | http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A050057000303 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050057000303 |
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