| フルテキストURL | A020045000108.pdf ( 1.7MB ) 公開日 2010-04-19
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| タイトル | Detection of K-ras Codon 12 Mutation in the Portal Blood during Surgery for Pancreatic Carcinoma |
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| 作成者 | Enoki, Tadahiko
Morita, Nobuyoshi
Inokuchi, Tomohiro
Tsushimi, Takahiro
Hayashi, Daisuke
Okamura, Keiji
Shinagawa, Hidetaka
Orita, Masahiko
Noshima, Shinji
Esato, Kensuke
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| 作成者ヨミ | エノキ, タダヒコ
モリタ, ノブヨシ
イノクチ, トモヒロ
ツシミ, タカヒロ
ハヤシ, ダイスケ
オカムラ, ケイジ
シナガワ, ヒデタカ
オリタ, マサヒコ
ノシマ, シンジ
エサト, ケンスケ
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| 作成者所属 | 山口大学医学部
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| 内容記述（抄録等） | Background and Aim : It is well known that pancreatic adenocarcinomas harber K-ras gene point mutations, which are frequently restricted to codon 12. Thus, the detection of K-ras codon 12 mutations in pancreatic or duodenal juice may did in the diagnosis of pancreatic adenocarcinomas. In the present study, we investigated whether or not portal blood collected during surgery for pancreatic adenocarcinoma contains the K-ras codon 12 mutation. Methods : During radical resection for pancreatic adenocarcinoma, 10ml of portal blood was taken twice ; first immediately after laparotomy, then just before resection. K-ras mutation was analyzed by a polymerase chain reaction using the primars corresponding to mutant alleles. Results : K-ras mutation was identefied in three of nine patients with pancreatic adenocarclinoma immediately before resection, while none of the patients were positive at the time of laparotomy. The K-ras status in the portal bllod did not correlate with microscopic venous or lymphataic invation. Conclusion : K-ras mutations were identified in portal bllod in some patients with pancreatis adenocarcinoma, which indicates that pancreatic cancer cells migrated into portal bllod during resection and that some adjuvant therapy during surgery may be necessary to cure the pancreatic cancer.
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| 本文言語 | eng
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| 著者キーワード | K-ras codon 12 mutation
liver metastasis
pancreas carcinoma
portal blood
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| 主題 | 医学
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University Graduate School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名別表記 | 山口医科大学紀要 |
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| 巻 | 45 |
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| 号 | 1-4 |
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| 開始ページ | 51 |
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| 終了ページ | 56 |
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| 発行日 | 1998-12 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A020045000108 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020045000108 |
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