| フルテキストURL | 2009010076.pdf ( 293.7KB ) 公開日 2010-04-16
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| タイトル | 9p21 index as estimated by dual-color fluorescence in situ hybridization is useful to predict urothelial carcinoma recurrence in bladder washing cytology |
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| 作成者 | Kawauchi, Shigeto
Sakai, Hajime
Ikemoto, Kenzo
Eguchi, Satoshi
Nakao, Motonao
Takihara, Hirofumi
Shimabukuro, Tomoyuki
Furuya, Tomoko
Oga, Atsunori
Matsuyama, Hideyasu
Takahashi, Mutsuo
Sasaki, Kohsuke
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| 作成者ヨミ | カワウチ, シゲト
ササキ, ハジメ
イケモト, ケンゾウ
エグチ, サトシ
ナカオ, モトナオ
タキハラ, ヒロフミ
シマブクロ, トモユキ
フルヤ, トモコ
オガ, アツノリ
マツヤマ, ヒデヤス
タカハシ, ムツオ
ササキ, コウスケ
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| 作成者別表記 | 河内, 茂人
池本, 健三
中尾, 素直
小賀, 厚徳
松山, 豪泰
高橋, 睦夫
佐々木, 功典
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| 作成者所属 | 山口大学大学院医学系研究科（医学）
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| 内容記述（抄録等） | Recent studies have shown that chromosome 9p21 locus is frequently deleted in the early stages of urothelial carcinogenesis. To study the predictive value of the 9p21 aberrations in recurrence of urothelial carcinoma of the urinary bladder, we applied dual-color fluorescence in situ hybridization for 9p21 and chromosome 9 centromere to the bladder washing cytology samples that were obtained from the patients with urothelial carcinoma of the urinary bladder treated by transurethral resection. For the evaluation, the 9p21 index was defined as the ratio of the mean number of 9p21 signals per nucleus for that of the chromosome 9 centromere signals per nucleus in each of the bladder washing cytology samples. The 9p21 index values of the bladder washing cytology samples with no (G0) cytologic atypia were significantly higher than those of the bladder washing cytology samples with moderate (G2) (P < .01) and severe (G3) (P < .001) cytologic atypia, but the index values did not statistically differ from those of the bladder washing cytology samples with mild (G1) cytologic atypia. Recurrence-free survival in the patients with a low 9p21 index value (<0.9) was significantly poorer in comparison with the patients with a high 9p21 index value (>0.9). Furthermore, 2 patients of bladder washing cytology G1 with a low 9p21 index value recurred much sooner than the other patients of the bladder washing cytology G1 category. These findings indicate that a decreased 9p21 index value is associated with recurrence of urothelial carcinoma of the urinary bladder, and the 9p21 index may be useful as a marker to identify patients with elevated risk of recurrence of urothelial carcinoma of the urinary bladder.
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| 本文言語 | eng
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| 著者キーワード | bladder washing cytology
fluorescence in situ hybridization
9p21 index
recurrence
urinary bladder
urothelial carcinoma
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Elsevier
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| NII資料タイプ | 学術雑誌論文 |
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| 査読の有無 | 査読あり |
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| ISSN | 0046-8177
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| NCID | AA00666191
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| 掲載誌名 | Human pathology : a clinicopathologic quarterly |
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| 巻 | 40 |
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| 号 | 12 |
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| 開始ページ | 1783 |
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| 終了ページ | 1789 |
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| 発行日 | 2009-12 |
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| DOI | info:doi/10.1016/j.humpath.2009.06.011 |
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| 関連情報URL(IsPartOf) | http://www.sciencedirect.com/science/journal/00468177
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| 権利関係 | Copyright 2009 Elsevier Inc. All rights reserved.
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| 著者版/出版社版 | 著者版 |
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| リポジトリID | 2009010076 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2009010076 |
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