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フルテキストURL2009010076.pdf ( 293.7KB ) 公開日 2010-04-16
タイトル9p21 index as estimated by dual-color fluorescence in situ hybridization is useful to predict urothelial carcinoma recurrence in bladder washing cytology
作成者Kawauchi, Shigeto
Sakai, Hajime
Ikemoto, Kenzo
Eguchi, Satoshi
Nakao, Motonao
Takihara, Hirofumi
Shimabukuro, Tomoyuki
Furuya, Tomoko
Oga, Atsunori
Matsuyama, Hideyasu
Takahashi, Mutsuo
Sasaki, Kohsuke
作成者ヨミカワウチ, シゲト
ササキ, ハジメ
イケモト, ケンゾウ
エグチ, サトシ
ナカオ, モトナオ
タキハラ, ヒロフミ
シマブクロ, トモユキ
フルヤ, トモコ
オガ, アツノリ
マツヤマ, ヒデヤス
タカハシ, ムツオ
ササキ, コウスケ
作成者別表記河内, 茂人
池本, 健三
中尾, 素直
小賀, 厚徳
松山, 豪泰
高橋, 睦夫
佐々木, 功典
作成者所属山口大学大学院医学系研究科(医学)
内容記述(抄録等)Recent studies have shown that chromosome 9p21 locus is frequently deleted in the early stages of urothelial carcinogenesis. To study the predictive value of the 9p21 aberrations in recurrence of urothelial carcinoma of the urinary bladder, we applied dual-color fluorescence in situ hybridization for 9p21 and chromosome 9 centromere to the bladder washing cytology samples that were obtained from the patients with urothelial carcinoma of the urinary bladder treated by transurethral resection. For the evaluation, the 9p21 index was defined as the ratio of the mean number of 9p21 signals per nucleus for that of the chromosome 9 centromere signals per nucleus in each of the bladder washing cytology samples. The 9p21 index values of the bladder washing cytology samples with no (G0) cytologic atypia were significantly higher than those of the bladder washing cytology samples with moderate (G2) (P < .01) and severe (G3) (P < .001) cytologic atypia, but the index values did not statistically differ from those of the bladder washing cytology samples with mild (G1) cytologic atypia. Recurrence-free survival in the patients with a low 9p21 index value (<0.9) was significantly poorer in comparison with the patients with a high 9p21 index value (>0.9). Furthermore, 2 patients of bladder washing cytology G1 with a low 9p21 index value recurred much sooner than the other patients of the bladder washing cytology G1 category. These findings indicate that a decreased 9p21 index value is associated with recurrence of urothelial carcinoma of the urinary bladder, and the 9p21 index may be useful as a marker to identify patients with elevated risk of recurrence of urothelial carcinoma of the urinary bladder.
本文言語eng
著者キーワードbladder washing cytology
fluorescence in situ hybridization
9p21 index
recurrence
urinary bladder
urothelial carcinoma
資料タイプtext
ファイル形式application/pdf
出版者Elsevier
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0046-8177
NCIDAA00666191
掲載誌名Human pathology : a clinicopathologic quarterly
40
12
開始ページ1783
終了ページ1789
発行日2009-12
DOIinfo:doi/10.1016/j.humpath.2009.06.011
関連情報URL(IsPartOf)http://www.sciencedirect.com/science/journal/00468177
権利関係Copyright 2009 Elsevier Inc. All rights reserved.
著者版/出版社版著者版
リポジトリID2009010076
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2009010076