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タイトルHistological analysis of the 'critical point' in follicular development in mice
作成者Kagabu, Satosi
Umezu, Motoaki
作成者ヨミカガブ, サトシ
ウメズ, モトアキ
作成者別表記利部, 聰
梅津, 元昭
作成者所属山口大学農学部
内容記述(抄録等)Aim: To histologically examine ovarian follicular development in cycling mice. Methods: Mice were observed at 13:00 h at each stage of the estrous cycle. The ovaries were cut into complete serial sections. All sections were observed, and the size of each follicle was measured by using a micrometer. Follicles with advanced atresia were excluded and non-atretic healthy follicles were differentiated from atretic follicles. Results: The measurement of the number of follicles in each stage of the estrous cycle, with reference to their size, showed that in each mouse, the number of small healthy follicles (100-249 μm in average diameter) was approximately 100 for all stages and the number of medium-sized healthy follicles (250-349 μm) was close to 20 in only the metestrus and diestrus stages. In contrast, large healthy follicles (≧350 μm) showed marked changes throughout the estrous stage. Many healthy large follicles were observed in the proestrus stage, but they disappeared in the estrus stage, which suggests that they have ovulated. This was supported by observations of oocytes resuming meiosis in large healthy follicles. Conclusion: As follicular atresia was frequently observed in follicles of 250-399 μm diameter, this size range may be a 'critical point' for atresia. The results suggest that there is a 'critical point' in follicular development, and that only follicles that pass this point will ovulate, while those that do not will become atretic follicles.
本文言語eng
著者キーワードfollicular atresia
Graafian follicle
mouse
ovarian follicles
ovulation
資料タイプtext
出版者Blackwell
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN1445-5781
NCIDAA11706516
掲載誌名Reproductive medicine and biology
3
3
開始ページ141
終了ページ145
発行日2004-09
DOIinfo:doi/10.1111/j.1447-0578.2004.00062.x
関連情報URL(IsPartOf)http://www.blackwell-synergy.com/loi/rmb?cookieSet=1
著者版/出版社版その他
リポジトリID2008010073
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2008010073