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フルテキストURLA020033000101.pdf ( 968.3KB ) 公開日 2010-04-19
タイトルInduction to Granulocytic Differentiation of Human Promyelocytic Leukemia Cells (HL-60) by Polyprenoic Acid (E5166)
作成者Sasaki, Kohsuke
Murakami, Tomoyuki
Ogino, Tetsuro
Kawasaki, Shoji
Okita, Kiwamu
Takahashi, Manabu
作成者ヨミササキ, コウスケ
ムラカミ, トモユキ
オギノ, テツロウ
カワサキ, ショウジ
オキタ, キワム
タカハシ, マナブ
作成者別表記佐々木, 功典
作成者所属山口大学医学部
内容記述(抄録等)The effects of synthesized polyprenoic acid, E5166,on human promyelocytic leukemia cell line, HL60, were examined. The cells continuously exposed to the drug in vitro underwent growth inhibition and granulocytic differentation. In the culture treated with E5166, the cell cycle progression was markedly inhibited and an accumukation of the cells in G1/0 phase was apparent on day 4 when a small number of granulocyte first appeared. Subsequently, the percentage of differentiated cellsin the culture increased continuously with the time of treatment and on day 7, 80% of cells acquired the morphological characteristics of mature granulocytes. The close relationship between cell kinetics and differentiation was suggested, although the mechanisms by which E5166 induces differentiation and exerts its antiproliferative effect on HL-60 are unknown.
本文言語eng
著者キーワードDifferentitation
Leukemia
polyprenoic acid
Flow cytometry
BrdUrd
Cell cycle
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
33
1
開始ページ1
終了ページ7
発行日1986-12
著者版/出版社版出版社版
リポジトリIDA020033000101
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020033000101