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フルテキストURLA020041000306.pdf ( 635.3KB ) 公開日 2010-04-19
タイトルThe Effect of Hyperthermia on Cerebral Energy Metabolism Studied with vivo 31P Nuclear Magnetic Resnance Spectrosccopy
作成者Tsuchida, Eiji
作成者ヨミツチダ, エイジ
作成者所属山口大学医学部
内容記述(抄録等)Energy metabolism in the Wistar rat brain was studied by means of in vivo nuclear magnetic resonance spectroscopy after heating. The 31P-spectra were recorded at 10 minutes after heating the brain to 44 or 45℃ (cortical temperature) for 30 minutes on 6 rats in each group. Thereafter, the 31P-spectra were repeatedly recorded until 1 hour after heating. The 31P-spectra showed no significant changes of pH and high-energy phosphate levels occurred for 1 hour after heating of the brain to 44℃ for 30 minutes. However, those determined 10 minutes after heating the brain to 45℃ for 30 minutes showed a statistically significant reduction of the PCr/Pi ratio without accompaning a pH shift and change in ATP concentration. No further changes occurred thereafter for 1 hour after heating of the brain. The heat-induced PCr/Pi ratio reduction observed in this study reflected mitochondrial dysfunction and not a decline in cerebral blood flow. The present study has demonstrated at least part of the heat-induced damage of the brain occurred at mitochondrial level in vivo, while cerebral enerfy metabolism was found to be preserved up to cortical brain temperature of 44℃.
本文言語eng
著者キーワードBackscattered electron imaging
Scanning electron microscopy Lymphocyte blastogenesis
Enzyme cytochemistry
Phytohemagglutinin
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
41
3-4
開始ページ89
終了ページ97
発行日1994-12
著者版/出版社版出版社版
リポジトリIDA020041000306
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020041000306