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フルテキストURLA020043000310.pdf ( 2.9MB ) 公開日 2010-04-19
タイトルEffect of an Angiotensin-Converting Enzyme Inhibitor on Smooth Muscle Myosin Isoforms in Afferent Arterioles from Spontaneously Hypertensive Rats
作成者Kawata, Yasunobu
作成者ヨミカワタ, ヤスノブ
作成者所属山口大学医学部
内容記述(抄録等)I used immunohistchemical analysis to examine the expression of smooth muscle myosin heavy chain (MHC) isoforms (SM1 and SM2) in renal arterioles from 20- week-old Wister Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). I also examined the effect of an angiotensin-converting enzyme inhibitor, enalapril, on the expression of MHC isoforms in renal afferent arterioles from SHR. SM1 was expressed in both afferent and efferent arterioles from WKY and SHR, but much less expressed in efferent arterioles compared with afferent arterioles. On the other hand, SM2 was only expressed in afferent arterioles, and was less expressed in vehicle SHR than WKY. The expression of SM1 and SM2 in afferent arterioles from enalapril-treated SHR for 6 weeks and WKY were more increased than those from vehicle SHR (WKY vs vehicle SHR; p < 0.01, vehicle SHR vs enalapril-treated SHR; p < 0.05, WKY vs enalapril-treated SHR; not significant). Thus, pressure load and the antihypertensive treatment resulted in the changes of the expression of smooth muscle MHC isoforms in renal afferent arterioles, sggesting that smooth muscle MHC isoforms in renal afferent arterioles may play an important role in the regulation of glomerular function in hypertension.
本文言語eng
著者キーワードSmooth muscle myosin heavy chain isoforms
Spontaneously hypertensive rat
Afferent arteriole
ACE inhibitor
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
43
3-4
開始ページ99
終了ページ106
発行日1996-12
著者版/出版社版出版社版
リポジトリIDA020043000310
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020043000310