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フルテキストURLA020006000107.pdf ( 4.0MB ) 公開日 2010-04-16
タイトルEXPERIMENTAL OBSERVATION OF RAT NEUROSECRETION UNDER DERANGED STEROID HORMONE MILIEU
作成者Inomoto, Kinya
作成者ヨミイノモト, キンヤ
作成者所属山口大学医学部
内容記述(抄録等)The neurosecretory phenomenon of rat was studied morphologically under some experimental conditions of high and low steroid hormone milieu. 1. Estradiol, progesterone, testosterone and MAD exert direct excitatory action on neurosecretion without any mediation of hypophysis. These four hormones prevent the neurosecretory cell from retrograde degeneration following hypophysectomy. 2. Cortisone affects extensively thalamic and hypothalamic area while DOCA loads neurosecretion heavily until some of cell undergoes degeneration due to exhaustion. 3. Effect of ACTH and synahorin on neurosecretion can be interpreted as that of hormones of corresponding target organs. 4. Castration result in nuclear pyknosis of some supraoptic cells. Slight increase in Gomori substance and in nuclear size were present in most of neurosecretory cells while adrenalectomy results in unclear pyknosis of some supraoptic cells and in loss of neurosecretory material. 5. Nuclear pyknosis in some cells and disappearance of Gomori substance are induced by such stress as formalin and needle pricks on tail. These results obtained suggest that presumed neurohumoral mechanism through which hypothalamus exerts its control over hypophysis may be neurosecretion itself. The results of the experiments may offer morphological foundition in favor of accepted supposition that neurosecretion provokes the potuitary adrenocortcial response to stress.
本文言語eng
主題薬学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
6
1-2
開始ページ37
終了ページ62
発行日1958-08-30
著者版/出版社版出版社版
リポジトリIDA020006000107
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020006000107