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フルテキストURLA020019000307.pdf ( 3.7MB ) 公開日 2010-04-16
タイトルThe Effects of Ethanol on ths Dog Purkinje Fiber
作成者Yamada, Akio
作成者ヨミヤマダ, アキオ
作成者所属山口大学医学部
内容記述(抄録等)The effects of ehanol on the slope of slow depolarization, rising time, threshold potential, membrane conductance and plateau duration in the action potential of dog Purkinje fiber were studied by means of intracellular eleectrode techniques. The concentration of ehanol used in the present experiments was ianged netween 0.1% and 0.2%. It was observed that 0.1% ethanol lowered the beating frequency with the change of excitability at the level of threshold potential and shrtened the plateau because of increased membrane conductance for potassium ion. No significant changes in both the slow depolarization phase and rising time in the action potential were observed. It was discussed that ethanol was effective to inhibit the fibrillation by the mechanisms of elevating the threshlod in slow depolarization and of increasing the membrane conductance for potassium in plateau. This would be the reason why whanol is clinically useful for preventing the fibrillation which appears at warming0up stage after the operation of heart with hypothermia.
本文言語eng
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
19
3-4
開始ページ149
終了ページ162
発行日1972-12
著者版/出版社版出版社版
リポジトリIDA020019000307
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020019000307