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タイトルInterleukin-2持続門脈内投与の肝切除後肝再生に及ぼす影響
タイトルヨミInterleukin 2 ジゾク モンミャクナイ トウヨ ノ カン セツジョゴ カンサイセイ ニ オヨボス エイキョウ
タイトル別表記Influence of Continuous Interleukin-2 Administration via the Portal Vein on Liver Regeneration after Partial Hepatectomy in Rats
作成者和田守, 憲二
作成者ヨミワダモリ, ケンジ
作成者別表記Wadamori, Kenji
作成者所属山口大学医学部
内容記述(抄録等)We have reported the efficacy of intra-arterial-combined immunochemotherapy including interleukin2 (IL-2) for unresectable hepatocellular carcinoma (HCC). To further test this therapy for prevention of intrahepatic recurrence after hepatectomy, the influence of IL-2 on liver regeneration was examined using the bromodeoxyuridine (BrdU) labeling index (LI) in 70% hepatectomized Donryu rats. In addition, gap junction appearance was analyzed using a monoclonal antibody (HAM 8). IL-2 (45,000 JRU/day) or saline was administered continuously via the portal vein immediately after hepatectomy. We also examined the influence of IL-2 on liver regeneration after hepatectomy with splenectomy. No difference in the weight of the liver, Serum albumin, GPT, or total bilirubin was observed in any groups at 1, 2, or 4 days after hepatectomy. Neither IL-2 nor splenectomy influenced BrdU LI at all three points. Gap junctions began to disappear after hepatectomy and reached a minimum on day 2 in all groups. Four days after hepatectomy, the density of the reappearing gap junctions was markedly lower in groups treated with IL-2 than in those receiving saline with or without splenectomy. However, the density at 6 days after hepatectomy in all groups was identical to the density in normal liver. Continuous portal infusion of IL-2 transiently disturbed gap junction reappearance during liver regeneration. However, no other parameters of liver regeneration or liver functions differed. These results suggest that intrahepatic IL-2 administration can be performed without serious complications after hepatectomy.
本文言語jpn
著者キーワード70%肝切除後肝再生
Interleukin-2 持続肝血管内投与
Gap junction
BrdU
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
44
6
開始ページ365
終了ページ373
発行日1995-12
著者版/出版社版その他
リポジトリIDB030044000606
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030044000606