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タイトル厚生省特定疾患『アミロイドーシス』 : その総論と発症機序に関して
タイトルヨミコウセイショウ トクテイ シッカン アミロイドーシス ソノ ソウロン ト ハッショウ キジョ ニカンシテ
タイトル別表記Amyloidosis designated as Intractable Disease by Ministry of Health and Welfare of Japan : A Review and its Pathogenesis
作成者石原, 得博
高橋, 睦夫
権藤, 俊一
河野, 裕夫
星井, 嘉信
田村, 克
内野, 文彌
作成者ヨミイシハラ, トクヒロ
タカハシ, ムツオ
ゴンドウ, トシカズ
カワノ, ヒロオ
ホシイ, ヨシノブ
タムラ, スグル
ウチノ, フミヤ
作成者別表記Ishihara, Tokuhiro
Takahashi, Mutsumo
Gondo, Toshikazu
Kawano, Hiroo
Hoshii, Yoshinobu
Tamura, Suguru
Uchino, Fumiya
作成者所属山口大学医学部
内容記述(抄録等)We describe as nomenclature, classification, statistics, clinicopathology, histology, histochemistory, and ultrastructure of amyloid and amyloidosis. Amyloidosis is a disease caused by deposition of amyloid proteins in various tissues and organs. Amyloid is morphologically characterized by its birefringence and dichroism after Congo red stain, and its ultrastructure. The classification of amyloid and amyloidosis is based on the amyloid fibril proteins, followed by a designation of the fibril protein precursor. To date, 15 proteins have been identified as constituents of amyloid fibrils in clinically diverse conditions. Amyloid proteins derived from serum amyloid A(AA) in secondary amyloidosis, immunoglobulin light chain (AL) in primary amyloidosis, transthyretin (ATTR) in familial amyloidotic polyneuropathy FAP) and systemic senile amyloidosis, β2-microglobulin (Aβ2M) in hemodialysis associated amyloidosis, and rarely immunoglobulin heavy chain (AH), apolipoprotein A l(AApoA 1) in FAP typeIII, gelsolin (AGel) in FAP typeIV. Deposition of Aβ amyloid derived from β protein are common findings in the brain of patients with Alzheimer's disease and cortical hemorrhage, AIAPP from amylin in islets of Langerhans of patients with diabetes typeII , and AANF from atrail natriuretic factor in the atrium of advanced age in human. The pathogenesis of amyloidosis is also discussed. Amyloid enhancing factor (AEF) is associated with several forms of amyloidosis and play an important role for the pathogenesis in experimental amyloidosis. Amyloid fibres are seen mainely in the interstitia of the various organs. Aggregates of amyloid fibrils have been observed in proximity to cells, oriented perpendicularly to. and merging with, the cell membrane. Inrracyoplasmic amyloid fibrils are noted in several cases, mainely in localized amyloidosis.
本文言語jpn
著者キーワードアミノイドーシス
免疫組織化学
SAA
FAP
透析
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
44
6
開始ページ297
終了ページ318
発行日1995-12
著者版/出版社版その他
リポジトリIDB030044000601
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030044000601