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タイトル食道癌に対する制癌剤の選択に関する基礎的研究と臨床応用
タイトルヨミショウクドウ ガン ニ タイスル セイガンザイ ノ センタク ニ カンスル キソテキ ケンキュウ ト リンショウテキ オウヨウ
タイトル別表記Chemosensitivity of Human Esophageal Cancer Cell Lines and Its Clinical Applications to Chemotherapy
作成者佐伯, 俊宏
作成者ヨミサエキ, トシヒロ
作成者別表記Saeki, Toshihiro
作成者所属山口大学医学部
内容記述(抄録等)To select effective anticancer agents for esophageal cancer, in vitro chemosensitivity was examined by the succinate dehydrogenase inhibition(SDI) method using six human esophageal cancer cell lines; YES-1, 2, 3, 4, 5, and 6. Nine kinds of drugs; VP-16, 5-FU, CDDP, MMC, ADM, VDS, MTX, PEP and BLM were used. VP-16 and 5-FU were effective against two cell lines using a low peak plasma concentration (PPC)×1/100, and VP-16 was effective against four at a PPC×1. CDDP was effective against three at a PPC×10. MMC and ADM were effective at higher doses, but the remaining drugs showed relatively poor efficacy. Based on the results of this study, VP-16(E), 5-FU(F) and CDDP(P) were administered to patients as follows. Between 1989 and 1994, 31 patients with thoracic esophageal cancer, who had undergone curative resection(Group 1), were treated with EFP as an adjuvant chemotherapy. Thirty-one patients consisted of 6 patients in stage 0, 2 in stage I , 2 in stage II, 6 in stage III, and 15 in stage IV. As the site of relapse after this treatment, local recurrence, cervical lymph nodes metastases and distant metastases were noted in 3 (9.7%), 5 (16.1%), and 2 (6.4%) of 31 patients, respectively. When compared with relapse in 83 patients who had curative resection without EFP between 1983 and 1989 (Group 2), the overall recurrence rate of distant metastases of 6.4% in Group 1 was lower than 18.1% in Group 2. As long-term results in Group 1, the overall 5-year survival rate is 47.2 %,and was higher than that (37.0%) in Group 2. The toxicities of EFP were mainly nausea and leucopenia , and were never life-threatening. This study suggests that adjuvant chemotherapy with EFP may improve the results of treatment for esophageal cancer.
本文言語jpn
著者キーワード食道癌
ヒト癌培養細胞株
制癌剤感受性試験
succinate dehydrogenase inibition test
術後補助化学療法
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
44
4
開始ページ201
終了ページ212
発行日1995-08
著者版/出版社版その他
リポジトリIDB030044000404
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030044000404