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フルテキストURL2008010281.pdf ( 499.2KB ) 公開日 2010-04-16
タイトルInfluence of immunosuppressants against Dirofilaria immitis infection in dogs
作成者Hayasaki, Mineo
Ohishi, Isamu
作成者ヨミハヤサキ, ミネオ
オオイシ, イサム
作成者別表記早崎, 峯夫
作成者所属山口大学農学部
内容記述(抄録等)Two immunosuppressive drugs, azathiopurine (AZP) and prednisolone (PDS), were examined on dogs experimentally infected with Dirofilaria immitis in order to estimate the involvement of immunological assail in rejecting the parasite by the host. AZP was orally administered to 3 dogs daily at a dosage of 1-10 mg/kg for a period from 3 days before infection until the end of the experiment. The dose was then varied and transiently ceased according to the severity of the side effects. PDS was subcutaneously administered daily to 2 dogs. They were administered 10 mg/kg of PDS from 3 days before infection to day 15 and 5.0-8.5 mg/kg from day 60 after infection to day 70. The serum D. immitis-specific antibody level assessed by an indirect hemagglutination test was steadily decreased in the AZP-medicated dogs. However, in the PDS-medicated dogs, the antibody titer was decreased until day 32 and, thereafter, was recovered. When all dogs were sacrificed between days 145-148, an average recovery rate of worms in both the AZP- and PDS-medicated dogs was 52.5% and 49.6%, respectively, while the controls showed 42.5%. The statistical analysis revealed no significant difference among the groups, indicationg that the administration of AZP and PDS was not effective in protecting the larvae from the host's immune attack.
本文言語eng
著者キーワードazathiopurine
Dirofilaria immitis
dog
immunosuppressant
prednisolone
資料タイプtext
ファイル形式application/pdf
出版者日本獣医学会
出版者ヨミニホン ジュウイ ガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0021-5295
NCIDAA10521639
掲載誌名Japanese journal of veterinary science
51
5
開始ページ955
終了ページ960
発行日1989
関連情報URL(IsPartOf)http://www.jstage.jst.go.jp/browse/jvms/-char/ja
Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis
著者版/出版社版出版社版
リポジトリID2008010281
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2008010281