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タイトル拡張型心筋症類似の心筋症ハムスター、UM=X7.1における心筋組織内コラーゲンの経時的変化とその意義
タイトルヨミカクチョウ ガタ シンキンショウ ルイジ ノ シンキンショウ ハムスター UM=X7.1 ニオケル シンキン ソシキナイ コラーゲン ノ ケイジテキ ヘンカ トソノ イギ
タイトル別表記Analysis of Cardiac Collagens in Cardiomyopathic Hamsters, UM-X7.1
作成者村田, 千鶴
作成者ヨミムラタ, チズル
作成者別表記Murata, Chizuru
作成者所属山口大学医学部
内容記述(抄録等)Dilated cardiomyopathy (DCM) is characterized with systolic dysfunction and dilatation of both ventricles. By histological examinations, interstitial fibrosis is commonly seen. In this study, cardiac collagens of DCM hamsters (UM-X7. 1) aged 8, 12, 16, 20 and 24 weeks were alalyzed by the colorimetric assay of hydroxyproline and by the densitometric assay of collagens which were separated by SDS-polyacrylamide gel electrophoresis (PAGE). Sex and age matched golden hamsters (GH) were used for control. The hydroxyproline concentration of left ventricles increased during aging in GH (8w 4. 13mg/g, 24w 5.80mg) and DCM (8w 4.88mg, 24w 7.40mg). SDS -PAGE of cardiac collagens of DCM showed no changes of total density of collagens during aging with samples containing same amount of hydroxyproline. In GH, however, the total density collagens decreased during aging. That is: (1) the hydroxyproline concentration of cardiac collagens of GH increased during aging but not the collagen concentration, and (2) the collagen concentration of DCM markedly increased during aging but not the hydroxyproline concentration. This is indicates that the rate of synthesis of cardiac collagens markedly increased during aging in DCM hamsters but not of hyroxylation of cardiac collagens. These results suggest the abnormal increase of unstable cardiac collagens causes to interstitial fibrosis of ventricles. This may result in systolic dysfunction and dilatation of ventricles which are characteristics of DCM.
本文言語jpn
著者キーワード拡張型心筋症
コラーゲン
ヒドロキシプロリン
加齢
ハムスター
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
42
3
開始ページ209
終了ページ215
発行日1993-06
著者版/出版社版その他
リポジトリIDB030042000304
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030042000304