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タイトル分子疫学的手法による院内感染の解明
タイトルヨミブンシ エキガクテキ シュホウ ニヨル インナイ カンセン ノ カイメイ
タイトル別表記Molecular Epidemiology of Nosocomial Infection
作成者中澤, 晶子
作成者ヨミナカザワ, テルコ
作成者別表記Nakazawa, Teruko
作成者所属山口大学医学部
内容記述(抄録等)To prevent nosocomial outbreaks, elucidation of the source of infection and the mode of transmission is the primary importance. Molecular epidemiology by using DNA fingerprinting and ribotyping is a powerful tool for such analysis, since typing by these methods is based on the whole genome structure. A nosocomial outbreak of Pseudomonas cepacia infection in immunocompromized patients was analyzed by DNA fingerprinting as well as by conventional methods and revealed that the outbreak was associated with contaminated nebulizers. DNA fingerprinting and ribotyping were evaluated with clinical isolates of Pseudomonas cepacia from various sources. Both the methods gave almost identical results, indicating the usefulness of these techniques. Typing by the plasmid profile was reliable only in limited cases. Conventional typing methods such as enzyme typing, bacteriocin typing, phage typing, and serotyping should be used with caution in nosocomial infection, because these are based on phenotypes that are changeable by few genetic events.
本文言語jpn
著者キーワード院内感染
Pseudomonas cepacia
分子疫学
DNA fingerprinting
ribotyping
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
42
3
開始ページ185
終了ページ191
発行日1993-06
著者版/出版社版その他
リポジトリIDB030042000301
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030042000301