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タイトル電撃化学療法におけるアドリアマイシンの細胞内移行動態の解析
タイトルヨミデンゲキ カガク リョウホウ ニオケル アドリアマイシン ノ サイボウナイ イコウ ドウタイ ノ カイセキ
タイトル別表記Analysis of Intra-cellar Influx of Adriamycin after Electrical Impulse Chemotherapy
作成者富恵, 博
作成者ヨミトミエ, ヒロシ
作成者別表記Tomie, Hiroshi
作成者所属山口大学医学部
内容記述(抄録等)To investigate the mechanism of electrical impluse chemotherapy, we administered such treatment using adriamycin (ADR) to rats inoculated AH109-A ascites hepatorr.a. The carcinostatic effect and intracellular influx of ADR were investigate by means of flowcytometry (FCM) and fluorescent microscopy. When rats bearing the AH109-A subcutaneous solid tumor were treated with ADR followed by spike wave loading, the T/C ratio (the tumor volume of the treatment group comnpared with that of the control group) on post-treatment day 7 was0.37±0.07, which was significantly lowerascompared with the values of 0.49±0.05 taken in the group given ADR alone (p<0.01). In rats inoculated AH109-A hepatoma into : abdiminal cavity given in vivo electrical impluse chemotherapy with ADR, intracellular concentration of drug measured by FCM was about 3 times higher than observed with the drug given alone. When electrical impluse chemotherapy was applied in vitro to AH109-A cells exposed to ADR, 1.25mg/ml, fluorescence microscory reveaiec that 50±0 cells were positive for the drug, significantly greater than the 21±9 cells observed v-. Ith the administration of ADR alone (p<0.01). It is suggested that spike wave electricla impulse chemotherapy induce eiectroporation of the cell membrane and permit the intracellular influx of a large amount of carcin: static agent which exerts a strong carcinostatic effect.
本文言語jpn
著者キーワード電撃化学療法
電気的穿孔現象
アドリアマイシン
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
41
6
開始ページ429
終了ページ437
発行日1992-12
著者版/出版社版その他
リポジトリIDB030041000608
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030041000608