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タイトル片腎摘後の阻血腎の代償性腎肥大に与えるサイクロスポリンの影響 : pair feeding model による検討
タイトルヨミカタ ジンテキゴ ノ ソケツジン ノ ダイショウセイ ジン ヒダイ ニ アタエル サイクロスポリン ノ エイキョウ : pair feeding model ニ ヨル ケントウ
タイトル別表記Effect of cyclosproin a upon compensatory renal hypertrophy combined with ishemic injury in a pair feeding rat model
作成者城嶋, 和孝
作成者ヨミジョウジマ, カズタカ
作成者別表記Jojima, Kazutaka
作成者所属山口大学医学部
内容記述(抄録等)Cyclosproin A (CyA) is a potent immunosuppressive agent which has a unique mode of action. It has been widely used in organ transplantation and has improved graft survival. However, a patiental harmful side effect, nephrotoxicity has been reported, by a number of investigators clinically and experimentally. The mechanism of this toxicity is still controversial. The purpose of this study is to test the affect of CyA on compensatory renal hypertrophy when the kidney is exposed to ischmia, utilizing a pair feeding model to minimize the effect to diet. The rats were divided into following four groups. Group 1 : nephrectomy only, group 2 : nephrectomy plus CyA, group 3 : nephrectomy olus ischemia, group 4 : identical to group 3 except CyA was administered. Forty five minutes of warm ischemia or simple expose was made on the remaining kidneys. All were pair fed. Rats of each group were given CyA 50mg/kg or vehice orally for eleven days. After the renal blood flow and the renal function were given CyA 50mg/kg or vehicle orally for eleven days. After the renal blood flow and the renal function were determined on day eleven, rats were sacrified and kidneys were removed and weighed. In coonclusion, the renal function significantly deteriorated in the CyA groups with or without ischemia and worse in the group with ischemia. However, kidney growth and renal blood flow were suppressed significantly only in group 4 compared to group 3. A synergic harmful effect of CyA and ischemia on compensatory renal hypertrophy was suspected.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
39
5
開始ページ569
終了ページ573
発行日1990-10
著者版/出版社版その他
リポジトリIDB030039000501
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030039000501