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フルテキストURLA020004000204.pdf ( 1.6MB ) 公開日 2010-04-16
タイトルAN OUTBLEAK OF ACUTE ARSENIC POISONING CAUSED BY ARSENIC CONTAMINATED SOY-SAUCE (SH?YU) : A CLINICAL REPORT OF 220 CACES
作成者Mizuta, Nobuo
Mizuta, Minoru
Ito, Fukashi
Ito, Tsunesuke
Uchida, Hiroyuki
Watanabe, Yutaka
Akama, Hiroshi
Murakami, Tadashi
Hayashi, Fumiya
Nakamura, Katsue
Yamaguchi, Takao
Mizuta, Wataru
Oishi, Shozo
Matsumura, Hiroshi
作成者ヨミミズタ, ノブオ
ミズタ, ミノル
イトウ, フカシ
イトウ, ツネスケ
ウチダ, ヒロユキ
ワタナベ, ユタカ
アカマ, ヒロシ
ムラカミ, タダシ
ハヤシ, フミヤ
ナカムラ, カツエ
ヤマグチ, タカオ
ミズタ, ワタル
オオイシ, ショウゾウ
マツムラ, ヒロシ
作成者所属山口大学医学部
内容記述(抄録等)In The preceding pages we have tried to drow a chinical picture of acute arsenic posioning fromsoy-sauce accidentally contaminated which occurred in the City of Ube, Yamaguchi Prefecture, in January 1956. The main symtoms observed in 220 cases out of the total 417 patients were edema of the face, gastrointestinal and upper resoiratory symptoms followed by skin lesion and neuriritic signs which occurred in a limited unmber of patienta in the late atage. In the majority of patients, the symptoms appeared 2 days after the intake of arsenic ond subsided gradually after the 5 th or 6 th day of illness, despite contibuous intake of the poison. These symtoms disappeared rapidly tow weeks after eliminating the arsenic contaminated sauce from the diet. Neuritic symptoms, on the other hand, began to get aggravated later in the second week after suspension of arsenic intake. The liver was palpable as enlarged for one or tow finger breadtha in mosa of the cases, andreturnd to the nomal size in convalescence. Electrocadiogram revealed abnormalities in Q-T interval and P-and T-waves. Ophthalmokogically conjunctivitis, central scotoma and neuro-retinitis were derected. Laboratory data indicated slight anemia, leukopenia, relative lymphocytosis, positive urinary urobilibogen in 60 to 80 % of the cases, normal electrolytes and urea clearance. Fecal occult blood was positive in may of the patients, and in some, occlt blood was demonstrable in gastric and duodenal juice. Chemical analysis of serum was suggestive of slight but definite degenerative changes such as decrease of nucleic acid in liver cells. Hepatic detoxicating function was impaired in about half of the case, but BSP test remained normal. Arsenic was demonstrated in urine in an appreciable concentration even tow weeks after the suspention of arsenic ingestion. A low arsenic concentration was also detected in both gastric and duodenal juice. The root portion of the hair sontained more arsenic than The rest of the hair. The duration of arsenic inogetion was tow oe three weeks in most of the cases, and aresenic content of the soy- sauce whichcaused this accident was estimated to be about 0.1mg per milliliter.
本文言語eng
主題薬学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
4
2
開始ページ131
終了ページ149
発行日1956-12-31
著者版/出版社版出版社版
リポジトリIDA020004000204
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020004000204