Japanese | English

トップページへ戻る

詳細

   
フルテキストURLフルテキストリンクなし
タイトル圧迫萎縮と飢餓萎縮における肝細胞の超微形態の形態計測学的検討
タイトルヨミアッパク イシュク ト キガ イシュク ニ オケル カンサイボウ ノ チョウビ ケイタイ ノ ケイタイ ケイソクガクテキ ケントウ
タイトル別表記A comparative morphometrical analysis of atrophic hapatocytes pressed by amyloid deposits and in starvation
作成者権藤, 俊一
作成者ヨミゲンドウ, トシカズ
作成者別表記Gendo, Toshikazu
作成者所属山口大学医学部
内容記述(抄録等)A comparative morphometrical study on the atrophy of hepatocytes was made using the point-counting method. Light and electron microscopical photographs of the murin hepatocytes of peripheral zone of the lobules were morphometrically evaluated in eperimental amyloidosis and in three days starvation. Mitochondria in the hepatpcytes pressed by amyloid deposits were morphologically tended to be aggregated in distribution, but the volume density of mitochondria was not increased and individual mitochondoria were slightly enlarged in size. On the other-hand, in the hepatocytes in stravation, the volume density of mitochondoria was increased and each of the mitochondoria was enlarged in size as 2.7 times as those of the control hepatocytes and decreased considerably in number. There was no increase of autophagpspmes in the hepatocytes in both conditions. The change of mitochondria and sutophagosomes do not reveal the increase of consumption of the organella, but represent the decrease of de novo synthesis of the organella. The volume density of rough endoplasmic reticulum (rER) was increased in the hepatocytes pressed by amyloid deposits. In starvation, the volume density of rER in the hepatocytes did not change and the desrease of amount of rER was more striking than in amyloidosis. It is speculated that the relatively developed rER in the hepatocytes pressed by amyloid deposits may show an enhancement of the synthesis of serum amyloid A protein by an amyloidogenic stimulation, and that the decrease of rER in the hepatocytes in starvation may reveal the decrease of protein synthesis.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
36
2
開始ページ107
終了ページ123
発行日1987-04
著者版/出版社版その他
リポジトリIDB030036000205
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030036000205