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タイトル拍動流体外循環における内臓域血行動態および血中ホルモン, 乳酸・ビルビン酸代謝の検討
タイトルヨミハクドウリュウ タイガイ ジュンカン ニ オケル ナイゾウイキ ケッコウ ドウタイ オヨビ ケッチュウ ホルモン ニュウサン ビルビンサン タイシャ ノ ケントウ
タイトル別表記A Study on Splanchnic Hemodynamics and Metabolism of Hormone, Lactate and Pyruvate during Pulsatile Extracorporeal Circulation
作成者野並, 芳樹
作成者ヨミノナミ, ヨシキ
作成者別表記Nonami, Yoshiki
作成者所属山口大学医学部
内容記述(抄録等)Effects of pulsatile perfusion on hemodynamics and metabolism of the splanchnic organs were investigated in adult mongrel dogs. Pulsatile perfusion was performed with a Pulsatile Bypass Pump (PBP) and blood flow was measured with an ultrasonic transit time flowmeter, a newly developed apparatus, capable of accurate measurement of both quick and slow blood flow. For hemodynamics, pulsatile and nonpulsatile total perfusion groups were compared, with regards to flow rate of 60 ml/kg/min, 80ml/kg/min and 100ml/kg/min under cardiac arrest. For metabolism, comparsion was made between the two groups at flow rate of 80ml/kg/min, with regards to blood sugar, angiotensin 2, plasma renin activity, catecholamine, aldosterone, insulin, pancreas-glucagon, total glucagon, lactate extraction ratio, pyruvate extraction ratio and excess lactate. Difference in hemodynamic state between both groups was noted in only those animals perfused at flow rate of 100 ml/kg/min, with significantly higher renal and portal blood flow in the pulsatile group. As for the differences in metabolism, the pulsatile group showed significantly lower plasma renin activity and adrenalin of renal blood, higher insulin pancreas-glucagon molar ratio of portal blood and more aerobic splanchnic metabolism. It was confirmed that pulsatile perfusion with PBP provides splanchnic circulation and metabolism in near-physiological state during extracorporeal circulation.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
35
5
開始ページ269
終了ページ281
発行日1986-10
著者版/出版社版その他
リポジトリIDB030035000502
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030035000502