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タイトル土壌由来のBacillus brevis1菌株の抗生物質学的研究 : (第2報) 抗生物質の単離とその諸性状
タイトルヨミドジョウ ユライ ノ Bacillus brevis 1 キン カブ ノ コウセイ ブッシツガク テキ ケンキュウ : ダイ2ホウ コウセイ ブッシツ ノ タンリ ト ソノ ショ セイジョウ
タイトル別表記Studies on a Strain of Bacillus brevis Isolated from Soil : Part II. Purification of Antibiotics and their Characteristics
作成者元木, 義信
作成者ヨミモトキ, ヨシノブ
作成者別表記Motoki, Yoshinobu
作成者所属山口大学医学部
内容記述(抄録等)Two kinds of antibiotics were harvested from a strain recently isolated. The supernatant of the culture at 28℃ showed a broad spectrum against Gram-positive and -negative bacteria. However, the supernatant of the culture at 37℃ showed growth inhibition only against Gram-positive bacteria. These substances were separated and purified through the successive steps involving column chromatography using Amberlite CG-50 and Sephadex G-25. These two antibiotics were identified as Gramicidin S and Polymyxin A. Furthermore, it was shown that these two antibiotics were simultaneously produced at 28℃. Gramicidin S was also produced at temperatures up to 40℃, however, Polymyxin A was not above 35℃. Two mutants lacking of polymyxin producing ability were obtained from the strain by acriflavin treatment.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
32
2
開始ページ161
終了ページ172
発行日1983-04
著者版/出版社版その他
リポジトリIDB030032000205
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030032000205