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タイトル制癌剤 5-Fluorouracil のエールリッヒ腹水癌細胞の呼吸代謝系並びに細胞分裂に及ぼす影響
タイトルヨミセイガンザイ 5-FLUOROURACIL ノ エールリッヒフクスイガンサイボウ ノ コキュウタイシャケイ ナラビニ サイボウブンレツ ニオヨボス エイキョウ
タイトル別表記Influence of 5-Fluorouracil on Respiratory Metabolism and Cell Division of Ehrlich Ascites Cancer Cell
作成者川口, 明夫
作成者ヨミカワグチ, アキオ
作成者別表記Kawaguchi, Akio
作成者所属山口大学医学部
内容記述(抄録等)The author investigated the anticancer effects of 5-FU on respiratory metabolism, glycolysis and cell division of Ehrlich ascites cancer (EAC), and obtained following results. 1) An action of 5-FU on EAC cells revealed to be decreasing QO_2 and Crabtree effect of EAC cells in vitro. 2) Decrement of pH in cell culture medium containing glucose was recognized, while, on the contrary, lactic acid quantity in reaction medium was increased. 3) Activities of NADH-DH and SDH of EAC cells were considerably inhibited in vitro. 4) On the mice that was intraperitoneally transplanted EAC cells, was contineously injected with 5-FU intraperitoneally after 5th of EAC cell inoculation, activity of SDH was slightly checked, but their daily changes was scarcely recognized in vivo. Concerning activity of NADH-DH, however, was recognized a tendency as same as it in vitro in the early period of 5-FU injection, on the contrary, in later period observed more remarkable increase than the control group. 5) Effect of 5-FU on cell division wes remarkably observed in the later period of contineous injection, ―increased of mitotic ratio in prophase stage, on the contrary, recognized remarkable decrease of ratio of cell division in anaphase or telophase. 6) Tumor index of treated group with 5-FU was recognized more less than control group in daily. 7) Specific action of 5-FU was clarified from above the mentioned results that effects of 5-FU on Ehrlich ascites cancer cell in vivo may be inhibit cell division until the stage of prophase, and block metabolic turnover of cell division.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
18
2
開始ページ109
終了ページ126
発行日1969-06
著者版/出版社版その他
リポジトリIDB030018000204
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030018000204