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フルテキストURLフルテキストリンクなし
タイトルトリクロロエチレン特にその代謝産物トリクロロ酢酸の代謝・排泄
タイトルヨミトリクロロエチレン トクニ ソノ タイシャ サンブツ トリクロロサクサン ノ タイシャ ハイセツ
タイトル別表記Metabolism and excretion of trichloroacetic acid as a metabolite of trichloroethylene in human subjects and rabbits
作成者中務, 康生
作成者ヨミナカツカサ, ヤスオ
作成者別表記Nakatsukasa, Yasuo
作成者所属山口大学医学部
内容記述(抄録等)The concentration of chloral hydrate (CH) and trichloroacetic acid (TCA) in the serum and urine in human subjects and rabbits were determioned after inhalation exposure to trichloroethylene (TRI). CH was detected only in the urine of the limited cases in both human subjects and rabbits the first day after TRI exposure, while not detected in the blood in all cases. TCA was detected in the serum and urine throughout more than a week after TRI exposure, while became undetectable in the urine earlier than in the blood. The pharmacokinetics of TCA administered in the blood of the rabbits were similar to that observed after TRIexposure. The total amounts of TCA excreted in the urine were only less than 20% of the administered doses. A decrease in TCA concentration and an increase in chlorine (Cl) concentration were seen in the TCA solution which was incubated at 37℃ after rabbit liver homogenate was added. Furthermore, an increased Cl excretion in the urine of rabbits was observed after intravenous administration of TCA. The results mentioned above indicate that Cl is a major metabolite of TCA.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
36
6
開始ページ353
終了ページ362
発行日1987-12
著者版/出版社版その他
リポジトリIDB030036000606
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030036000606