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フルテキストURLフルテキストリンクなし
タイトル拘束ストレス状況下におけるレセルピンの作用
タイトルヨミコウソク ストレス ジョウキョウ カ ニ オケル レセルピン ノ エイキョウ
タイトル別表記Effects of reserpine stress-induced various responses in rats
作成者岸本, 千種
牛島, 逸子
水木, 泰
山田, 通夫
作成者ヨミキシモト, チグサ
ウシジマ, イツコ
ミズキ, ヤスシ
ヤマダ, ミチオ
作成者別表記Kishimoto, Chigusa
Ushijima, Itsuko
Mizuki, Yasushi
Yamada, Michio
作成者所属山口大学医学部
内容記述(抄録等)The effects of reserpine, an amine depletor, on the thermoregulation, gastric ulceration and emotional responses were compared with those of N^6-cyclohexyl adenosine (CHA), an aadenosine A-1 receptor agonist in stressed and non stressed rats. Subcutaneous injection of reserpine produced hypothermia and gastric lesions even in non-stressed rats, and potentiated the hypothermia but did not produce gastric lesions in stressed rats. To the contrary, intracerebral injection of reserpine produced hyperthrmis snd did not produce gastric lesions in stressed or non-stressed rats. Both intracerbral and subcutaneous injection os CHA produced hypothermia and gastric lesions, which were potentiated in stressed rats. Reserpine (s. c.)-induced gastric lesiona in stressed rats were not inhibited by caffeine, an adenosine receptor antagonist, suggesting that the lesion formation by reserpine may not be due to the activation of central adenosine A-1 receptor. Stress-induced hyperemotional behaviors such as struggling and defecation were inhabited by either subcutaneous or intraventricular injection of reserpine and CHA. These results suggest that reserpine-induced hypothermia and gastric ulceration is peripheral action, and the inhibitory effects of reserpine and CHA on stress-induced hyperemotinal responses may be due to the central actions.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
38
2
開始ページ119
終了ページ125
発行日1989-04
著者版/出版社版その他
リポジトリIDB030038000205
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030038000205