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タイトル脳動脈閉塞に対する急性期血行再開のための補助治療の実験的研究 : 人為的低血圧、人工血液、高気圧酸素の効果
タイトルヨミノウドウミャク ヘイソク ニ タイスル キュウセイ ケッコウ サイカイ ノ タメノ ホジョ チリョウ ノ ジッケンテキ ケンキュウ : ジンイテキ テイケツアツ ジンコウ ケツエキ コウキアツ サンソ ノ コウカ
タイトル別表記Hyperbaric oxygen, perfluorochemical and artificial hypotension as an adjunct to acute reperfusion of middle cerecral arterial occlusion in cats
作成者山下, 哲男
作成者ヨミヤマシタ, テツオ
作成者別表記Yamashita, Tetsuo
作成者所属山口大学医学部
内容記述(抄録等)The effect of hyperbaric oxygen (HBO), perfluorochemical (PFC) and hypotensive reperfusion on postischemic cerebral edema was studied. The middle cerebral artery in cats was transorbitally occluded for 3 hrs and reperfused for 3 hrs. The cats whose CBF decreased to lower than 10ml/100g/min by the occlusion were used. The HBO (2atm, pure oxygen) was started one hour after the occlusion and continued for one hour. The mean arterial blood pressure was lowered artificially about 50mmHg from the previous value using adenosine triphosphate and dipyridamole just before and during the reperfusion. The value of CBF 3 hours after reperfusion was 8.2±11.0ml in the control group(n=10), 18.1±12.2ml in the hypotension group(n=6), 25.4±14.2ml in the PFC group(PFC with hypotension, n=5), and 27.5±9.0ml in the HBO group(HBO with hypotension, n=6). The ICP increased to 90.0±22.6mmHg in the control group and in the hypotension group to 37.7±10.1mmHg, in the PFC group to 43.2±17.1mmHg and in the HBO group to 29.8±20.9mmHg. The water content of the affected hemisphere was 79.7±0.5% in the control group, 79.1±0.5% in the hypotension group and 78.3±0.5% in the HBO group. These results suggest that the hypotensive reperfusion decreases vascular bed and reduces the strain on the vasoparalytic vascular wall thus improving the vasogenic edema. The PFC and the HBO help the metabolism of the vascular wall to improve during ischemia and maintain the strength of the vessel wall against intravascular pressure and reduce the edema. In conclusion, HBO, Pfc, and hypotensive reperfusion are useful as adjunts to actue cerebral revascularization.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
37
2
開始ページ113
終了ページ120
発行日1988-04
著者版/出版社版その他
リポジトリIDB030037000201
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030037000201