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フルテキストURL2007020200.pdf ( 2.7MB ) 公開日 2010-04-16
タイトルIntrauterine transplantation of isogenic pancreatic islets in experimental diabetic rats
タイトルヨミジッケンテキ トウニョウビョウ ラット ニタイスル スイトウ ノ シキュウクウ ナイ ドウケイカン イショク
タイトル別表記実験的糖尿病ラットに対する膵島の子宮腔内同系間移植
作成者Sakonju, Iwao
Taura, Yasuho
Nakaichi, Munekazu
Nakama, Sanenori
Kagabu, Satoshi
作成者ヨミサコンジュ, イワオ
タウラ, ヤスホ
ナカイチ, ムネカズ
ナカマ, サネノリ
カガブ, サトシ
作成者別表記左近允, 巌
田浦, 保穂
中市, 統三
中間, 實徳
利部, 聰
作成者所属山口大学農学部
内容記述(抄録等)The effect of intrauterine transplantation (IU group) as a potential immunologically privileged site on the diabetic state of the recipient was compared with that of conventional intraperitoneal transplantation (IP group) using Fischer 344 rats. Islets were isolated from the pancreata of normal rats and transplanted into the uterus and peritoneal cavity of the isogenic rats with experimental diabetes, which were treated with estradiol benzoate and progesterone. Although all the rats in both groups became normoglycemic within 4 days after transplantation, all of those in the IU group relapsed into a diabetic state up to the 20th day after transplantation. On the other hand, 6 of 8 rats in the IP group remained normoglycemic throughout the experimental period. Weight gain and diminution of urinary glucose excretion in the IU group were significantly lower than those in the IP group (P<0.01). The glycosylated hemoglobin level in the IU group did not differ significantly from that in the IP group, but the serum level of fructosamine in the IU group was significantly higher than that in the IP group (P<0.01). These results indicate that the response to fluctuations of blood glucose of islets in the uterine cavity is less than that of islets in the peritoneal cavity. Histologically, islets were observed to be aggregated in the uterine cavity, however the number of cells decreased markedly with time. Although this study demonstrated that blood glucose was normalized by transplantation of islets into the uterine cavity of diabetic rats, long-term survival of the islets in this location was not obtained.
本文言語eng
著者キーワードdiabetes
immunologically privileged site
pancreatic islets transplantation
rat
資料タイプtext
ファイル形式application/pdf
出版者日本獣医学会
出版者ヨミニホン ジュウイ ガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0916-7250
NCIDAA10796138
掲載誌名The journal of veterinary medical science
56
4
開始ページ729
終了ページ733
発行日1994
関連情報URL(IsPartOf)http://www.jstage.jst.go.jp/browse/jvms/-char/ja
著者版/出版社版出版社版
リポジトリID2007020200
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2007020200