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タイトル正常ヒトkeratinocyteのSCC抗原産生能に及ぼすカルシウムの影響
タイトルヨミセイジョウ ヒト keratinocyte ノ SCC コウゲン サンセイノウ ニ オヨボス カルシウム ノ エイキョウ
タイトル別表記Effects of Calcium on the Production of Squamous Cell Carcinoma Antigen in Normal Human Keratinocytes
作成者津永, 長門
作成者ヨミツナガ, ナガト
作成者別表記Tsunaga, Nagato
作成者所属山口大学医学部
内容記述(抄録等)Squamous cell carcinoma antigen (SCC antigen) is a member of serine protease inhibitor's family, and appears in the differentiated types of malignant and nonmalignant squamous cells. This study shows the effects of calcium on the production of SCC antigen in normal human keratinocytes. The keratinocytes were treated with calcium with final concentration of 0.15, 0.5, 1.0 and 2.0mM for up to 5 days. mRNA expression and cytoplasmic contents of SCC antigen were significantly increased by 0.5 and 1.0mM calcium, but the release of SCC antigen into the medium rather decreased as the calcium concentrations were increased, showing the different behaviors in the production and release of SCC antigen. The immunohistochemical studies using a specific monoclonal antibody against SCC antigen also demonstrated that the intensity of staining was increased significantly in the calcium treated keratinocytes. These results indicated that calcium would influence the production and release of SCC antigen in keratinocyte, which should be involved in the proliferation and the differentiation of keratinocyte.
本文言語jpn
著者キーワードSCC抗原
karatinocyte
カルシウム
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
43
6
開始ページ419
終了ページ426
発行日1994-12
著者版/出版社版その他
リポジトリIDB030043000606
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030043000606