Japanese | English

トップページへ戻る

詳細

   
フルテキストURL2007020192.pdf ( 4.6MB ) 公開日 2010-04-16
タイトルDevelopmental hormonal profiles in rdw rats with congenital hypothyroidism accompanying increased testicular size and infertility in adulthood
作成者Umezu, Motoaki
Kagabu, Satoshi
Jiang, Jiany Y.
Niimura, Sueo
Sato, Eimei
作成者ヨミウメズ, モトアキ
カガブ, サトシ
Jiang, Jiany Y.
ニイムラ, スエオ
サトウ, エイメイ
作成者別表記利部, 聰
作成者所属山口大学農学部
内容記述(抄録等)Congenital hypothyroid mutant male rdw rats have enlarged testes in adulthood with dwarfism accompanied by infertility. To explain how rdw rats acquire enlarged testes in adulthood, we compared age-matched normal (N) rats at various developmental stages for blood levels of hormones, thyroxine (T4), follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T), and investigated whether T4 therapy (rdw+T4) from 3 weeks of age (w) until adulthood could induce recovery of fertility in rdw rats, as well as how rdw+T4 affected hormonal patterns. Testes weights of rdw rats were higher than those of N rats at 19 w in adulthood though it was low during development. Serum T4 values in rdw rats were markedly lower than those in N rats but steadily increased up to 19 w. The serum FSH values in rdw rats were lower than those in N rats at all ages, and neither serum LH nor T value was significantly different at any age. The testes weight of rdw+T4 rats was significantly higher than that of N rats at 13 w with recovered growth, and was higher than that of rdw rats at 19 w. When they were mated with proestrous females after 16 w, all females became pregnant and gave birth to a normal number of pups. The T4 and FSH values of rdw+T4 rats were significantly higher than those in rdw rats, but similar to those in N rats in adulthood. The results suggest that even low levels of circulating thyroid hormone (TH) in rdw rats stimulate the development of their testes, probably through Sertoli cells, resulting in the enlarged adult testes without fertility, and that a sufficient circulating TH level from the immature stage plays a pivotal role in restoring mating activity, probably through FSH-mediated action towards adulthood.
本文言語eng
著者キーワードcongenital hypothyroidism
male rdw rats
serum FSH
testis enlargement
infertility
thyroxine therapy
資料タイプtext
ファイル形式application/pdf
出版者Japanese Society of Animal Reproduction
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0916-8818
NCIDAA10936678
掲載誌名The Journal of reproduction and development
50
6
開始ページ675
終了ページ684
発行日2004
DOIinfo:doi/10.1262/jrd.50.675
関連情報URL(IsPartOf)http://www.jstage.jst.go.jp/browse/jrd/-char/en
著者版/出版社版出版社版
リポジトリID2007020192
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2007020192