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タイトルColchicineとCepharanthin併用による実験的アミロイド症の発症抑制について
タイトルヨミColchicine ト Cepharanthin ヘイヨウ ニ ヨル ジッケンテキ アミロイドショウ ノ ハッショウ ヨクセイ ニ ツイテ
タイトル別表記Inhibitory Effect of Colchicine in Combination with Cepharanthin on Experimental Amyloidosis
作成者長沢, 孝明
石原, 得博
内野, 文彌
作成者ヨミナガサワ, タカアキ
イシハラ, トクヒロ
ウチノ, フミヤ
作成者別表記Nagasawa, Takaaki
Ishihara, Tokuhiro
Uchino, Fumiya
作成者所属山口大学医学部
内容記述(抄録等)We investigated the role of colchicine (Col.) in conbination with cepharanthin (Ceph.) on the inhibition of amyloid deposits. ICR mice were treated with 0.2ml intraperitoneal injection of mixture of complete Freund's adjuvant and Mycobacterium butyricum according to Ram's method. The mice were divided 5 groups and administered subcutaneously once a day as follows ; 1) saline (0.02ml), 10 times, 2) Col. (20μg/25g), 5 times and saline (0.02ml), 10 times, 3) Col. (20μg/25g), 5 times and Ceph. (1.25μg/25g). 10 times, 4) Col. (20μg/25g), 5 times and Ceph. (25μg/25g). 10 times, and 5) Col (12.5μg/25g), 5 times and Ceph. (1.25μg/25g). 10 times. The mice were sacrificed at one day after last administration. The results were as follows ; 1) Col. (20μg/25g) in combination with Ceph (1.25μg/25g, 25μg/25g) was more significantly effective on inhibition of amyloid induction than Col. (20μg/25g) only, and 2) Col. (20μg/25g) in combination with Ceph. (1.25μg/25g) reduced significantly death rate due to secondary reaction of Col. We consider that Col. (25μg/25g) in combination with Ceph. (1.25μg/25g) was adequate in regard to inhibitory effect of amyloid induction and reduction of death rate due to secondary reaction on experimental amyloidosis.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
34
5
開始ページ369
終了ページ372
発行日1985-10
著者版/出版社版その他
リポジトリIDB030034000502
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030034000502