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タイトルGABA-bレセプター興奮の中枢プリン性機構への影響
タイトルヨミGABA-b レセプターコウフン ノ チュウスウ プリン セイ キコウ エ ノ エイキョウ
タイトル別表記The role of GABA-b receptor activity in central purinergic system in mice
作成者兼行, 浩史
牛島, 逸子
増本, 茂樹
小原, 奈美
水木, 泰
山田, 通夫
作成者ヨミカネユキ, ヒロシ
ウシジマ, イツコ
マシモト, シゲキ
オバラ, ナミ
ミズキ, ヤスシ
ヤマダ, ミチオ
作成者別表記Kaneyuki, Hiroshi
Ushijima, Itsuko
Mashimoto, Shigeki
Obara, Nami
Mizuki, Yasushi
Yamada, Michio
作成者所属山口大学医学部
内容記述(抄録等)A behavioral study was performed in an attempt to clarify an interaction between the GABA-b and the adenosine A_1 receptors in aggressive behaviors induced by clonidine in mice. Mice administered high doses of clonidine (20-30mg/kg i.p.) exhibited aggressive behaviors such as biting and attacking. Baclofen (1-5mg/kg), a GABA-b receptor agonist, inhabited the aggressive behaviors induced by clonidine (20mg/kg) in dose-dependent manner. Caffeine (5-10mg/kg), an adenosine (A_1>A_2) receptor antagonist, markedly potentiated the aggressive behaviors. The inhibitory effect og baclofen (1mg/kg) on the aggressive behaviors induced by clonidine (20mg/kg) was antagonized by caffeine (5mg/kg). Furthermore the stimulatory effedt of caffeine (5mg/kg) was reversed by baclofen. Aminooxyacetic acid (AOAA : 30mg/kg), a GABA transaminase inhabitor, also reduced clonidine (30ng/kg) induced aggressive behaviors. The inhibitory effect of AOAA tended to be increaced by bicuculline (2mg/kg), a GABA-a receptor antagonist, but did not significantly. The inhibitory effect of combined treatment with AOAA and bicuculline on the aggressive behaviors was antagonized by caffeine (1mg/kg), whereas the stimulatory effect of caffeine on the behaviors was reversed by combined treatment with these drugs. The results suggest that since either baclofen (GABA-b receptor agonist) or AOAA (endogenous GABA) in hibits colonidine-induced aggressive behaviors which are potentiated by caffeine, an adenosine receptor antagonist, these agents may be, in part, similar to the mode of action of adenosine receptor agonist.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
37
5
開始ページ389
終了ページ394
発行日1988-10
著者版/出版社版その他
リポジトリIDB030037000510
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030037000510