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タイトル笑気、ペントバルビタールの中枢神経系サブタンスP受容体結合に及ぼす影響
タイトルヨミショウキペントバルビタール ノ チュウスウ シンケイケイ サブタンスP ジュヨウタイ ケツゴウ ニ オヨボス エイキョウ
タイトル別表記Effects of nitrous oxide or prntobarbital on substance P receptor function in the rat central nervous system
作成者山本, 智久
作成者ヨミヤマモト, トモヒサ
作成者別表記Yamamoto, Tomohisa
作成者所属山口大学医学部
内容記述(抄録等)The effects of nitrous oxide (N_2O : 75%) or pentobarbital (PB : 80mg/kg intraperitoneal) on substance P (SP) synaptic transmission in the central nervous system were examined in 23 rats. For evaluation of SP receptor function, specific binding of [^<125>I] -Bolton Hunter SP was determined, using in vitro quantitative autoradiography. The number od receptors (Bmax) and affinity constant (Ka) in the discrete 12 regions of the central nervous system were determined by equilibrium binding method following by Scatchard analysis. In the N_2O group, the Bmax significantly decreased by 22% in spinal cord (laminae I-II), but increased significantly by 41% in locus coelureus (LC) and by 31% in cental gray at the end of 2-hour N_2O exposure as compared to the awake control values. These changes became insignificant within 12 hours after the end of N_2O exposure. In the PB group, the Bmax significantly increased by 30% in LC, but decreased By 21-32% in hippocampus (HIP), amygdala (AMY), septal nucleus (SEP) or caudate-putamen (CP), the Ka significantly increased by 144, 133 and 109% in solitary nucleus, SEP and CP, respectively, at 2 hours after the administration of PB, as compared to awake control values. The Bma in HIP, AMY and SEP was remained decreased at 12hours after PB anesthesia. These results suggest that N_2O and PB differentially affect SP receptor functions in the specific regions of the cental nervous system.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
39
2
開始ページ193
終了ページ201
発行日1990-04
著者版/出版社版その他
リポジトリIDB030039000207
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030039000207