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フルテキストURLA050055000304.pdf ( 674.8KB ) 公開日 2010-04-19
タイトルA possible association of single-nucleotide polymorphisms in the alpha-helix coiled-coil rod homologue gene with psoriasis in a japanese population
作成者Yamaguchi, Michiya
Tanaka, Akemi
Muto, Masahiko
作成者ヨミヤマグチ, ミチヤ
タナカ, アケミ
ムトウ, マサヒコ
作成者別表記山口, 道也
田中, 朱美
武藤, 正彦
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)The α-helix coiled-coil rod homologue (HCR) gene is known to be associated with the susceptibility of various races to psoriasis vulgaris (PV). This study aimed to analyze single-nucleotide polymorphisms (SNPs) in HCR in Japanese PV patients and investigate the association between these SNPs and PV in the Japanese population. The PV group comprised 75 PV patients from our hospital; the control group, 75 healthy individuals. By using the direct sequencing method, we analyzed SNPs in HCR at exons 4, 13/14, and 18, genetic polymorphisms in which are associated with susceptibility to PV in Caucasian and Taiwanese populations. We then investigated the association between these SNPs and PV. The association between PV and HCR -404^*T, HCR-1802^*T, and HCR-2406^*T was statistically significant. Other SNPs were not statistically significant at 5% level. Compared with the previous study in Finnish and Taiwanese populations, in our study, the frequencies of SNPs at the risk alleles were lower in both PV patients and healthy controls. HCR-2406^*G showed the most frequent SNPs (17.3% vs 4.0% in controls; odds ratio = 5.03, 95% confidence interval = 1.37-18.5; p = 0.015). These observations suggest that HCR may be a candidate gene for susceptibility to PV in the Japanese population.
本文言語eng
著者キーワードpsoriasis
HCR
SNPs
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
55
3-4
開始ページ43
終了ページ49
発行日2008
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050055000304
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050055000304