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タイトルモルモット心房筋の張力頻度関係および張力回復に及ぼす揮発性麻酔薬の効果
タイトルヨミモルモット シンボウ キン ノ チョウリョク ヒンド カンケイ オヨビ チョウリョク カイフク ニ オヨボス キハツ セイ マスイ ヤク ノ コウカ
タイトル別表記Effects of volatile anesthetics on force interval relationships in guinea-pig atrial preparations
作成者坂, 康雄
作成者ヨミサカ, ヤスオ
作成者別表記Saka, Yasuo
作成者所属山口大学医学部
内容記述(抄録等)Depressant effects of halothane, enflurance and isoflurance on isolated guinea pig right atrial muscles bathed in Tyrode's solution at 30℃ were examined. Contractions were elicited by stimulation through external field electrodes while tension was recorded continuously. Frequency-force relationships at stimulation rates of 0.1, 0.2, 0.5 and 1Hz were studied. The pD_2 values of these volatile anesthetics at each stimulation rates were not different significantly, suggesting the frequency-independent depressions of these anesthetics. Interval-strength relationships at time intervals of 0.3~20 sec during 1Hz-stimulation were also studied. Mechanical restitution curves after converting to logistic function reached a peak at 8~20sec and were fitted well to double exponential functions with time constants of 200~600 msec (k_1) and 2~6sec (k_2). All volatile anesthetics depressed the magnitude constants for fast response in a dose dependent manner. Accordingly, at high concentrations, mechanical restitution curves were fitted to single exponential functions. Halothane and enflurane did not alter time constants k_1, k_2 significantly, while isoflurane increased k_2 significantly. These results suggest that the mechanisms of myocardial depressant effects are different between these anesthetics.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
38
2
開始ページ127
終了ページ135
発行日1989-04
著者版/出版社版その他
リポジトリIDB030038000206
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030038000206