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フルテキストURLA050055000103.pdf ( 1.8MB ) 公開日 2010-04-19
タイトルThe free radical scavenger edaravone protects hair cells against aminoglycoside toxicity
作成者Arai, Tsuguyuki
Sugahara, Kazuma
Mikuriya, Takefumi
Miyauchi, Yuji
Hirose, Yoshinobu
Hashimoto, Makoto
Shimogori, Hiroaki
Yamashita, Hiroshi
作成者ヨミアラキ, ツグウキ
スガハラ, カズマ
ミクリヤ, タケフミ
ミヤウチ, ユウジ
ヒロセ, ヨシノブ
ハシモト, マコト
シモゴオリ, ヒロアキ
ヤマシタ, ヒロシ
作成者別表記菅原, 一真
御厨, 剛史
橋本, 誠
下郡, 博明
山下, 裕司
作成者所属山口大学医学部
内容記述(抄録等)Reactive oxygen species are involved in inner ear hair cell death induced by aminoglycosides. Therefore, inhibition of free radicals can prevent hair cell death. The antioxidant, edaravone has been used clinically in Japan. In this study, we evaluated whether edaravone can protect hair cells against aminoglycoside-induced cytotoxicity in cultured mouse utricles. Utricles from CBA/N mice were cultured in medium containing neomycin alone (1 mM), or neomycin plus edaravone. Hair cells cultured with neomycin alone were damaged after 24 hours. Survival of hair cells cultured with neomycin plus edaravone (30 or 100 μM) was significantly greater than that of hair cells cultured with neomycin alone. Immunohistochemistry showed the production of 4-hydroxy-2-nonenal in utricles cultured with neomycin but not in utricles cultured with neomycin plus edaravone (100 μM). These results suggest that the inhibibion of reactive oxygen species production by edaravone protects hair cells. In addition, high concentrations of edaravone did no show cytotoxicity.
本文言語eng
著者キーワードhair cell
aminoglycoside
hydroxy radical
Edaravone
ototoxicity
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
55
1-2
開始ページ15
終了ページ20
発行日2008
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050055000103
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050055000103