Japanese | English

トップページへ戻る

詳細

   
フルテキストURLA050054000303.pdf ( 495.9KB ) 公開日 2010-04-19
タイトルRegulation of insulin signaling via myosin motor protein and actin cytoskeletal network
作成者Nakamori, Yoshitaka
Emoto, Masahiro
Tanizawa, Yukio
作成者ヨミナカモリ, ヨシタカ
エモト, マサヒロ
タニザワ, ユキオ
作成者別表記中森, 芳宜
江本, 政広
谷澤, 幸生
作成者所属山口大学医学部
内容記述(抄録等)Impairment of systemic insulin action causes insufficient glucose uptake to cells and compensatory hyper-secretion of insulin from pancreatic β-cells. This insulin-resistant state promotes development of type 2 diabetes, obesity, hypertension, dyslipidemia, and atherosclerosis. Numerous attempts have been made to clarigy this pathogenesis and molocular mechanisms of insulin resistance. Tumor necrosis factor-α(TNF-α) is one of adipocytokines and a major factor causing insulin resistance. This cytokine attenuates insulin signaling by phosphorylation of insulin receptor substrate-1(IRS-1) Ser residues. However little is known about the precise molecular mechanisms. Recently we reported that IκB kinase-β(IKK-β) interacted with IRS-1, and phosphorylated IRS-1 Ser^<307> through molecular motor and actincytoskeleton. In this review, we overview this unique molecular mechanism and propose a new model that molecular motor and cytoskeletal network organize signaling cross-talk.
本文言語eng
著者キーワードNEMO
IKK-γ
Myo1c
IRS-1
TNF-α
insulin resistance
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
54
3-4
開始ページ33
終了ページ35
発行日2007
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050054000303
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050054000303