| フルテキストURL | A050053000102.pdf ( 775.8KB ) 公開日 2010-04-19
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| タイトル | Down-regulation of Ras / Akt Signaling and Hippocampal Neuronal Death following Transient Global Ischemia-Reperfusion in Rat brain |
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| 作成者 | Ying, jun Cui
Fukuda, Shiro
Hirata, Takao
Matayoshi, Hiroaki
Matsumoto, Mishiya
Sakabe, Takefumi
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| 作成者ヨミ | フクダ, シロウ
ヒラタ, タカオ
マタヨシ, ヒロアキ
マツモト, ミシヤ
サカベ, タケフミ
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| 作成者所属 | 山口大学医学部
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| 内容記述（抄録等） | Apotosis is one of the components of delayed neuronal death in the hippocampal CA1 following transient cerebral ischemia. However, the precise signal transduction for inducing this type of death is not fully determined. Recent research has shown that oncogenis Ras protein plays a role in regulation of cell survival and death. We hypothesized that apoptosis in delayed neuronal death is regulated with Ras and its signaling cascades. We examined the temporal profile of Ras and its downstream cascade following transient forebrain ischemia (15 min) in rat brain. Neuronal death was inconsistetly observed in the CA1 of the hippocampus (HE staining) 2 days after ischemia, whereas most neurons in the CA1 showed marked damage 3 days ofter ischemia. These damaged neurons exhibited positive TdT dUTP nick end labeling staining. α-Fodrin breakdown product in the hippocampus increased time dependently, 2 days and 3 days after reperfusion (by 14 and 25 times for 145-, 150-kDa, and by 30-40% for 120-kDa, respectively). The amounts of Ras and phospho-Akt were significantly decreased by approximately 30-50%. The results suggest that delayed neuranal death in the hippocampal CA1 following transient forebrain ischemia is characterized by an apoptotic nature and associated with and inhibition of the Ras-Akt cascade.
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| 本文言語 | eng
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| 著者キーワード | Ras
Akt
ischemia-reperfusion
hippocampus
apoptosis
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| 主題 | 医学
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University School of Medicine
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| NII資料タイプ | 紀要論文 |
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 巻 | 53 |
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| 号 | 1-2 |
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| 開始ページ | 5 |
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| 終了ページ | 12 |
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| 発行日 | 2006 |
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| 関連情報URL(IsPartOf) | http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A050053000102 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050053000102 |
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