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フルテキストURLA050053000102.pdf ( 775.8KB ) 公開日 2010-04-19
タイトルDown-regulation of Ras / Akt Signaling and Hippocampal Neuronal Death following Transient Global Ischemia-Reperfusion in Rat brain
作成者Ying, jun Cui
Fukuda, Shiro
Hirata, Takao
Matayoshi, Hiroaki
Matsumoto, Mishiya
Sakabe, Takefumi
作成者ヨミフクダ, シロウ
ヒラタ, タカオ
マタヨシ, ヒロアキ
マツモト, ミシヤ
サカベ, タケフミ
作成者所属山口大学医学部
内容記述(抄録等)Apotosis is one of the components of delayed neuronal death in the hippocampal CA1 following transient cerebral ischemia. However, the precise signal transduction for inducing this type of death is not fully determined. Recent research has shown that oncogenis Ras protein plays a role in regulation of cell survival and death. We hypothesized that apoptosis in delayed neuronal death is regulated with Ras and its signaling cascades. We examined the temporal profile of Ras and its downstream cascade following transient forebrain ischemia (15 min) in rat brain. Neuronal death was inconsistetly observed in the CA1 of the hippocampus (HE staining) 2 days after ischemia, whereas most neurons in the CA1 showed marked damage 3 days ofter ischemia. These damaged neurons exhibited positive TdT dUTP nick end labeling staining. α-Fodrin breakdown product in the hippocampus increased time dependently, 2 days and 3 days after reperfusion (by 14 and 25 times for 145-, 150-kDa, and by 30-40% for 120-kDa, respectively). The amounts of Ras and phospho-Akt were significantly decreased by approximately 30-50%. The results suggest that delayed neuranal death in the hippocampal CA1 following transient forebrain ischemia is characterized by an apoptotic nature and associated with and inhibition of the Ras-Akt cascade.
本文言語eng
著者キーワードRas
Akt
ischemia-reperfusion
hippocampus
apoptosis
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
53
1-2
開始ページ5
終了ページ12
発行日2006
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050053000102
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050053000102