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フルテキストURLA050066000301.pdf ( 581.7KB ) 公開日 2019-12-19
タイトルDetermination of compatibility of fosaprepitant dimeglumine and magnesium sulfate injections by high-performance liquid chromatography
作成者Ozaki, Masakazu
Kouda, Kyoji
Furukawa, Hiroyuki
Kitahara, Takashi
作成者ヨミオザキ, マサカズ
コウダ, キョウジ
フルカワ, ヒロユキ
キタハラ, タカシ
作成者別表記尾﨑, 正和
幸田, 恭治
古川, 裕之
北原, 隆志
作成者所属山口大学大学院医学系研究科(医学)
山口大学医学部附属病院
内容記述(抄録等)Fosaprepitant dimeglumine relieves nausea and vomiting caused by highly emetogenic chemotherapy agents such as high-dose cisplatin. Magnesium has renoprotective effects against cisplatin-induced damage. Thus, both drugs are sometimes used concomitantly, but administering them together intravenously may cause occlusion of the in-line filter. We aimed to clarify the extent to which the delivery of intravenous fosaprepitant dimeglumine is reduced by magnesium sulfate. Fosaprepitant dimeglumine was combined with magnesium sulfate and then filtered. Two ratios and concentrations of magnesium sulfate were tested (1:1 and 7:3 corresponding to 1.5 mg/mL fosaprepitant dimeglumine solution to 3.85% and 0.99% magnesium sulfate solution (v/v), respectively). The concentration of fosaprepitant dimeglumine in the filtrates was measured via high-performance liquid chromatography to determine the rate of decline in fosaprepitant dimeglumine. These experiments were performed in triplicate. When the ratio of fosaprepitant dimeglumine to magnesium sulfate was 1:1, the maximum rate of decline for fosaprepitant dimeglumine was 38.67%. At a ratio of 7:3, the maximum rate of decline was 7.62%. Fosaprepitant dimeglumine likely reacted with magnesium sulfate, which might inhibit the efficacy of fosaprepitant. To prevent this, we recommend flushing the in-line filter with 50 mL of normal saline before and after the administration of fosaprepitant dimeglumine.
本文言語eng
著者キーワードfosaprepitant dimeglumine
magnesium sulfate
drug compounding
high-performance liquid chromatography
infrared spectroscopy
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
66
3-4
開始ページ45
終了ページ51
発行日2019
著者版/出版社版出版社版
リポジトリIDA050066000301
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050066000301