| フルテキストURL | A050066000301.pdf ( 581.7KB ) 公開日 2019-12-19
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| タイトル | Determination of compatibility of fosaprepitant dimeglumine and magnesium sulfate injections by high-performance liquid chromatography |
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| 作成者 | Ozaki, Masakazu
Kouda, Kyoji
Furukawa, Hiroyuki
Kitahara, Takashi
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| 作成者ヨミ | オザキ, マサカズ
コウダ, キョウジ
フルカワ, ヒロユキ
キタハラ, タカシ
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| 作成者別表記 | 尾﨑, 正和
幸田, 恭治
古川, 裕之
北原, 隆志
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| 作成者所属 | 山口大学大学院医学系研究科（医学）
山口大学医学部附属病院
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| 内容記述（抄録等） | Fosaprepitant dimeglumine relieves nausea and vomiting caused by highly emetogenic chemotherapy agents such as high-dose cisplatin. Magnesium has renoprotective effects against cisplatin-induced damage. Thus, both drugs are sometimes used concomitantly, but administering them together intravenously may cause occlusion of the in-line filter. We aimed to clarify the extent to which the delivery of intravenous fosaprepitant dimeglumine is reduced by magnesium sulfate. Fosaprepitant dimeglumine was combined with magnesium sulfate and then filtered. Two ratios and concentrations of magnesium sulfate were tested (1:1 and 7:3 corresponding to 1.5 mg/mL fosaprepitant dimeglumine solution to 3.85% and 0.99% magnesium sulfate solution (v/v), respectively). The concentration of fosaprepitant dimeglumine in the filtrates was measured via high-performance liquid chromatography to determine the rate of decline in fosaprepitant dimeglumine. These experiments were performed in triplicate. When the ratio of fosaprepitant dimeglumine to magnesium sulfate was 1:1, the maximum rate of decline for fosaprepitant dimeglumine was 38.67%. At a ratio of 7:3, the maximum rate of decline was 7.62%. Fosaprepitant dimeglumine likely reacted with magnesium sulfate, which might inhibit the efficacy of fosaprepitant. To prevent this, we recommend flushing the in-line filter with 50 mL of normal saline before and after the administration of fosaprepitant dimeglumine.
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| 本文言語 | eng
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| 著者キーワード | fosaprepitant dimeglumine
magnesium sulfate
drug compounding
high-performance liquid chromatography
infrared spectroscopy
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 巻 | 66 |
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| 号 | 3-4 |
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| 開始ページ | 45 |
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| 終了ページ | 51 |
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| 発行日 | 2019 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A050066000301 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050066000301 |
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