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フルテキストURLA050066000104.pdf ( 830.3KB ) 公開日 2019-09-20
タイトルUtility of real-time tissue elastography in the sequential evaluation of liver fibrosis in patients with chronic hepatitis C
作成者Hanazono, Tadasuke
Hidaka, Isao
Maeda, Masaki
Saeki, Issei
Iwamoto, Takuya
Ishikawa, Tsuyoshi
Takami, Taro
Yamasaki, Takahiro
Sakaida, Isao
作成者ヨミハナゾノ, タダスケ
ヒダカ, イサオ
マエダ, マサキ
サエキ, イッセイ
イワモト, タクヤ
イシカワ, ツヨシ
タカミ, タロウ
ヤマサキ, タカヒロ
サカイダ, イサオ
作成者別表記花園, 忠相
日髙, 勲
前田, 雅喜
佐伯, 一成
岩本, 拓也
石川, 剛
高見, 太郎
山﨑, 隆弘
坂井田, 功
作成者所属山口大学大学院医学系研究科(医学)
山口大学医学部附属病院
内容記述(抄録等)Liver fibrosis is related to hepatocarcinogenesis in patients with chronic hepatitis C. Real-time tissue elastography (RTE) is a useful tool for evaluating liver fibrosis. In this study, we investigated the clinical utility of RTE to sequentially evaluate liver fibrosis in 30 patients with chronic hepatitis C undergoing interferon-based therapy. We compared the change in liver fibrosis index measured by RTE before and after treatment with the change in aminotransferase-to-platelet ratio index. In addition, we compared them across patients who were divided into two groups based on pretreatment alanine transaminase (ALT) level. Liver fibrosis index at pretreatment and at achievement of sustained virological response were 2.27 and 1.94 (p=0.0003), respectively. The aminotransferase-to-platelet ratio index also decreased significantly from 0.78 to 0.40 (p<0.0001). The liver fibrosis index showed significant improvement in both the ALT elevated group (ALT≥31 IU/L) (p=0.0265) and the persistently normal ALT group (ALT<30 IU/L) (p=0.0234). By contrast, the aminotransferase-toplatelet ratio index did not show significant improvement in the persistently normal ALT group (p=0.2813). We consider RTE as one of the non-invasive modalities, which can replace liver biopsy for sequential evaluation of liver fibrosis in patients with chronic hepatitis C.
本文言語eng
著者キーワードreal-time tissue elastography
liver fibrosis
HCV
interferon
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
66
1-2
開始ページ29
終了ページ35
発行日2019
著者版/出版社版出版社版
リポジトリIDA050066000104
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050066000104