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フルテキストURLA050066000103.pdf ( 2.6MB ) 公開日 2019-09-20
タイトルOverexpression of runt-related transcription factor-1 at invasive front in oral squamous cell carcinoma is associated with lymph node metastasis and poor prognosis
作成者Hisano, Takahiro
Cui, Dan
Harada, Koji
Kimura, Tokuhiro
Mishima, Katsuaki
Ikeda, Eiji
作成者ヨミヒサノ, タカヒロ
ハラダ, コウジ
キムラ, トクヒロ
ミシマ, カツアキ
イケダ, エイジ
作成者別表記久野, 高博
崔, 丹
原田, 耕志
木村, 徳宏
三島, 克章
池田, 栄二
作成者所属山口大学大学院医学系研究科(医学)
内容記述(抄録等)This study aims to examine clinical significance of Runt-Related Transcription Factor-1 (RUNX1) in oral squamous cell carcinoma (OSCC). RUNX1 expression was analyzed by immunohistochemistry in 43 patients with OSCC. The clinical significance of RUNX1 expression was evaluated by Chi-square test, Kaplan-Meier method and Cox regression model. The expression of RUNX1 at invasive front was significantly higher than that at central part of tumor (P < 0.01). OSCC patients with high RUNX1-Labeling Index (LI) at invasive front had significantly shorter overall survival period (P < 0.05) as compared with low RUNX1-LI at invasive front. Poorer prognosis of patients with higher RUNX1-LI at invasive front was supported by the data that the RUNX1-LI at invasive front was statistically correlated with poor differentiation (P < 0.05), invasiveness (P < 0.01), and post-operative lymph node metastasis (P < 0.05). Moreover, high RUNX1-LI at invasive front was demonstrated to be an independent prognostic factor for unfavorable overall survival (P < 0.05). Our findings suggest for the first time that overexpression of RUNX1 at the invasive front in OSCC can be a valuable marker to evaluate lymph node metastasis as well as a promising predictor of poor prognosis.
本文言語eng
著者キーワードlymph node metastasis
oral squamous cell carcinoma
prognosis
runt-related transcription factor-1
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
66
1-2
開始ページ15
終了ページ27
発行日2019
著者版/出版社版出版社版
リポジトリIDA050066000103
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050066000103