| フルテキストURL | A050066000103.pdf ( 2.6MB ) 公開日 2019-09-20
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| タイトル | Overexpression of runt-related transcription factor-1 at invasive front in oral squamous cell carcinoma is associated with lymph node metastasis and poor prognosis |
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| 作成者 | Hisano, Takahiro
Cui, Dan
Harada, Koji
Kimura, Tokuhiro
Mishima, Katsuaki
Ikeda, Eiji
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| 作成者ヨミ | ヒサノ, タカヒロ
ハラダ, コウジ
キムラ, トクヒロ
ミシマ, カツアキ
イケダ, エイジ
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| 作成者別表記 | 久野, 高博
崔, 丹
原田, 耕志
木村, 徳宏
三島, 克章
池田, 栄二
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| 作成者所属 | 山口大学大学院医学系研究科（医学）
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| 内容記述（抄録等） | This study aims to examine clinical significance of Runt-Related Transcription Factor-1 (RUNX1) in oral squamous cell carcinoma (OSCC). RUNX1 expression was analyzed by immunohistochemistry in 43 patients with OSCC. The clinical significance of RUNX1 expression was evaluated by Chi-square test, Kaplan-Meier method and Cox regression model. The expression of RUNX1 at invasive front was significantly higher than that at central part of tumor (P < 0.01). OSCC patients with high RUNX1-Labeling Index (LI) at invasive front had significantly shorter overall survival period (P < 0.05) as compared with low RUNX1-LI at invasive front. Poorer prognosis of patients with higher RUNX1-LI at invasive front was supported by the data that the RUNX1-LI at invasive front was statistically correlated with poor differentiation (P < 0.05), invasiveness (P < 0.01), and post-operative lymph node metastasis (P < 0.05). Moreover, high RUNX1-LI at invasive front was demonstrated to be an independent prognostic factor for unfavorable overall survival (P < 0.05). Our findings suggest for the first time that overexpression of RUNX1 at the invasive front in OSCC can be a valuable marker to evaluate lymph node metastasis as well as a promising predictor of poor prognosis.
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| 本文言語 | eng
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| 著者キーワード | lymph node metastasis
oral squamous cell carcinoma
prognosis
runt-related transcription factor-1
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 巻 | 66 |
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| 号 | 1-2 |
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| 開始ページ | 15 |
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| 終了ページ | 27 |
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| 発行日 | 2019 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A050066000103 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050066000103 |
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